MicroRNA signature in liver cancer

被引：45
作者：
Ghafouri-Fard, Soudeh [1 ]
Tamizkar, Kasra Honarmand [1 ]
Hussen, Bashdar Mahmud [2 ]
Taheri, Mohammad [3 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Dept Med Genet, Tehran, Iran
[2] Hawler Med Univ, Coll Pharm, Pharmacognosy Dept, Erbil, Iraq
[3] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2021年 / 219卷
关键词：
miRNA; Liver cancer; Hepatocellular carcinoma; EPITHELIAL-MESENCHYMAL TRANSITION; HEPATOCELLULAR-CARCINOMA PROGRESSION; CELL-PROLIFERATION; PROMOTES APOPTOSIS; UP-REGULATION; METASTASIS; EXPRESSION; INVASION; CONTRIBUTES; HEPATOMA;
D O I：
10.1016/j.prp.2021.153369
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Liver cancer is the 7th utmost frequent neoplasm and the 4th principal source of cancer deaths. This malignancy is linked with several environmental and lifestyle-related factors emphasizing the role of epigenetics in its path-ogenesis. MicroRNAs (miRNAs) have been regarded as potent epigenetic mechanisms partaking in the patho-genesis of liver cancer. Dysregulation of miRNAs has been related with poor outcome of patients with liver cancer. In the current manuscript, we provide a concise review of the results of recent studies about the role of miRNAs in the progression of liver cancer and their diagnostic and prognostic utility.
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页数：21
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