Comparative In Vitro Activities of Nemonoxacin (TG-873870), a Novel Nonfluorinated Quinolone, and Other Quinolones against Clinical Isolates

被引：61
作者：
Lauderdale, Tsai-Ling [1 ]
Shiau, Yih-Ru
Lai, Jui-Fen
Chen, Hua-Chien [2 ]
King, Chi-Hsin R. [2 ]
机构：
[1] Natl Hlth Res Inst, Div Infect Dis, Zhunan 350, Taiwan
[2] TaiGen Biotechnol Co Ltd, Taipei, Taiwan
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 03期
关键词：
RESISTANCE TSAR PROGRAM; ANTIMICROBIAL RESISTANCE; TAIWAN SURVEILLANCE; PATHOGENS;
D O I：
10.1128/AAC.01197-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The in vitro antibacterial activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, against 770 clinical isolates were investigated. Nemonoxacin (tested as its malate salt, TG-875649) showed better in vitro activity than ciprofloxacin and levofloxacin against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenzae. The in vitro activity of TG-875649 was also comparable to or better than that of moxifloxacin against these pathogens, which included ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus and levofloxacin-resistant Streptococcus pneumoniae.
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页码：1338 / 1342
页数：5
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