Impact of Preterm Birth on Neurodevelopmental Disorders in South Korea: A Nationwide Population-Based Study

Neurodevelopmental disorder (NDD) in preterm infants has become of great interest. We aimed to investigate the impact of preterm birth on the proportion of NDD using nationwide data provided by the Korean National Health Insurance Service. We included 4894 extremely preterm or extremely low-birth-weight (EP/ELBW; <28 weeks of gestation or birth weight < 1000 g) infants, 70,583 other preterm or low-birth-weight (OP/LBW; 28-36 weeks of gestation or birth weight < 2500 g) infants, and 264,057 full-term infants born between 2008 and 2015. We observed their neurodevelopment until 6 years of age or until the year 2019, whichever occurred first. Diagnoses of NDDs were based on the World Health Organization's International Classification of Diseases 10th revision. An association between preterm birth and NDD was assessed using a multivariable logistic regression model. There was a stepwise increase in the risk of overall NDD with increasing degree of prematurity, from OP/LBW (adjusted odds ratio 4.46; 95% confidence interval 4.34-4.58), to EP/ELBW (16.15; 15.21-17.15). The EP/ELBW group was strongly associated with developmental delay (21.47; 20.05-22.99), cerebral palsy (88.11; 79.89-97.19), and autism spectrum disorder (11.64; 10.37-13.06). Preterm birth considerably increased the risk of NDD by the degree of prematurity.