Ruthenium-Catalyzed Hydrogenation of Nitriles: Insights into the Mechanism

被引：152

作者：

Reguillo, Rebeca ^{[1
]}

Grellier, Mary ^{[1
]}

Vautravers, Nicolas ^{[1
]}

Vendier, Laure ^{[1
]}

Sabo-Etienne, Sylviane ^{[1
]}

机构：

[1] Univ Toulouse, Chim Coordinat Lab, CNRS, UPS,INPT, F-31077 Toulouse, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 23期

关键词：

PRIMARY AMINES; COMPLEXES; LIGANDS; IMINE; DEHYDROGENATION; BENZONITRILE; REACTIVITY; ACTIVATION; REDUCTION; HYDRIDE;

D O I：

10.1021/ja102759z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hydrogenation of benzonitrile into benzylannine is catalyzed under very mild conditions by the ruthenium bis(dihydrogen) complex RuH2(H-2)(2)(PCyp(3))(2), incorporating two tricyclopentylphosphines. Two key intermediates have been isolated, resulting from the activation of benzonitrile at early stages of activation, i.e., either N-coordination through the nitrite function or first hydrogenation with benzylimine formation, followed by, thanks to C-H activation, coordination at ruthenium as an orthometalated ligand.

引用

页码：7854 / +

页数：3

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