NMR spectroscopy in drug discovery and development: Evaluation of physico-chemical properties

被引：10
|
作者：
Zloh, Mire [1 ,2 ]
机构：
[1] UCL, UCL Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England
[2] Univ Business Acad, Fac Pharm, Trg Mladenaca 5, Novi Sad 21000, Serbia
来源：
ADMET AND DMPK | 2019年 / 7卷 / 04期
关键词：
logP; qNMR; drug solubility; DOSY; pharmaceutical formulations; H-1-NMR SPECTROSCOPY; PARTITION-COEFFICIENTS; VALIDATION; LIPOPHILICITY; METHODOLOGY; SOLUBILITY;
D O I：
10.5599/admet.737
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Determination of physico-chemical properties of compounds is one of the corner-stones in selection of hit molecules for further progression into lead development in the modern drug discovery process. The speed of traditional analyses and limited quantities of hit molecules are obstacles for efficient acquisition of experimental data. Herein, the range of applications of quantitative nuclear magnetic resonance (NMR) spectroscopy as a fast technique used to evaluate solubility, log P and pKa are discussed.
引用
收藏
页码：242 / 251
页数：10
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