The huge clinical potential of microbiota in the treatment of pancreatic cancer: The next frontier

被引：5

作者：

Zhang, Zhilin ^{[1
]}

Tang, Dong ^{[2
,3
]}

机构：

[1] Yangzhou Univ, Clin Med Coll, Yangzhou, Jiangsu, Peoples R China

[2] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Inst Gen Surg, Clin Med Coll,Dept Gen Surg, Yangzhou, Peoples R China

[3] Yangzhou Univ, Northern Jiangsu Prov Hosp, Inst Gen Surg, Clin Med Coll,Dept Gen Surg, Yangzhou 225001, Peoples R China

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2022年 / 1877卷 / 03期

关键词：

Pancreatic cancer; Microbiota; Clinical potential; Diagnosis; Treatment; COLORECTAL-CANCER; ORAL MICROBIOTA; GUT MICROBIOTA; DEPLETION; THERAPY; INTERVENTION; CHEMOTHERAPY; GEMCITABINE; DESMOPLASIA; RESISTANCE;

D O I：

10.1016/j.bbcan.2022.188733

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Microbes and their metabolites are found in all body organs; their interaction with body organs can influence inflammation, immunity, and cancer development. Pancreatic cancer development is closely related to intestinal, intrapancreatic, and oral flora. The microbiota plays a regulatory role in pancreatic cancer's malignant progression and treatment resistance. Thus, the study of microbiota-host interactions has emerged as a new hot topic in pancreatic cancer treatment, with microbiota control demonstrating significant clinical potential. This review summarizes recent advances in the clinical diagnosis and treatment of pancreatic cancer, emphasizing the enormous potential for operating microbiota in pancreatic cancer treatment.

引用

页数：10

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