Protective role of superoxide dismutase in iron toxicity in yeast

被引:0
作者
Wisnicka, R
Krzepilko, A
Wawryn, J
Krawiec, Z
Bilinski, T
机构
[1] Pedag Univ Rzeszow, PL-35310 Rzeszow, Poland
[2] Agr Univ Lublin, Zamosc Coll Agr, PL-22400 Zamosc, Poland
来源
BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL | 1998年 / 44卷 / 03期
关键词
superoxide dismutase; catalase; cytochrome c peroxidase; iron; hydrogen peroxide; yeast mutants;
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It has been found that yeast mutants deficient in cytosolic superoxide dismutase CuZnSOD are hypersensitive to ferrous iron. In contrast mutants that are deficient in catalases and cytochrome c peroxidase do not differ from the standard strain in this respect. These findings suggest that iron toxicity may depend on the redox status of the cell. They also shed light on the role of superoxide dismutases in preventing the toxic effects of oxygen.
引用
收藏
页码:635 / 641
页数:7
相关论文
共 17 条
[1]  
[Anonymous], AGE PIGMENTS
[2]   OXYGEN-TOXICITY AND MICROBIAL EVOLUTION [J].
BILINSKI, T .
BIOSYSTEMS, 1991, 24 (04) :305-312
[3]   IS HYDROXYL RADICAL GENERATED BY THE FENTON REACTION INVIVO [J].
BILINSKI, T ;
KRAWIEC, Z ;
LICZMANSKI, A ;
LITWINSKA, J .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 130 (02) :533-539
[4]  
BILINSKI T, 1988, OXYRADICALS MOL BIOL, P109
[5]   REGULATION OF CATALASE SYNTHESIS IN SACCHAROMYCES-CEREVISIAE BY CARBON CATABOLITE REPRESSION [J].
CROSS, HS ;
RUIS, H .
MOLECULAR & GENERAL GENETICS, 1978, 166 (01) :37-43
[6]  
FRIDOVICH I, 1984, METHOD ENZYMOL, V105, P59
[7]   GLUTATHIONE-PEROXIDASE IN YEAST - PRESENCE OF THE ENZYME AND INDUCTION BY OXIDATIVE CONDITIONS [J].
GALIAZZO, F ;
SCHIESSER, A ;
ROTILIO, G .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 147 (03) :1200-1205
[8]  
IMLAY JA, 1991, J BIOL CHEM, V266, P6957
[9]  
LESSUISSE E, 1990, BIOCHIM BIOPHYS ACTA, V1038, P253
[10]  
PIFFERI PG, 1981, ANN CHIM, V18, P729