The role of cationic antimicrobial peptides in innate host defences

被引：1082
|
作者：
Hancock, REW
Diamond, G
机构：
[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada
[2] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Anat Cell Biol & Injury Sci, Newark, NJ 07103 USA
来源：
TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 09期
关键词：
D O I：
10.1016/S0966-842X(00)01823-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cationic antimicrobial peptides are found in all living species. A single animal can contain >24 different antimicrobial peptides, which fall into four structural classes. These peptides are produced in large quantities at sites of infection and/or inflammation and can have broadspectrum antibacterial, antifungal, antiviral, antiprotozoan and antisepsis properties. In addition, they interact directly with host cells to modulate the inflammatory process and innate defences.
引用
收藏
页码：402 / 410
页数：9
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