Immunovirotherapy for the Treatment of Glioblastoma and Other Malignant Gliomas

被引：14

作者：

Estevez-Ordonez, Dagoberto ^{[1
]}

Chagoya, Gustavo ^{[1
]}

Salehani, Arsalaan ^{[1
]}

Atchley, Travis J. ^{[1
]}

Laskay, Nicholas M. B. ^{[1
]}

Parr, Matthew S. ^{[1
]}

Elsayed, Galal A. ^{[1
]}

Mahavadi, Anil K. ^{[1
]}

Rahm, Sage P. ^{[1
]}

Friedman, Gregory K. ^{[1
,2
]}

Markert, James M. ^{[3
]}

机构：

[1] Univ Alabama Birmingham, Dept Neurosurg, 1060 Fac Off Tower 510 20th St South, Birmingham, AL USA

[2] Univ Alabama Birmingham, Dept Pediat, Div Pediat Hematol Oncol, Birmingham, AL USA

[3] Univ Alabama Birmingham, Dept Neurosurg Neurosurg Pediat & Cell Dev & Inte, 1060 Fac Off Tower 510 20th St South, Birmingham, AL 35294 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2021年 / 32卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Glioblastoma; Immunovirotherapy; Oncolytic virus; Herpes simplex virus (HSV-1); Brain tumors; Oncolytic virotherapy; SIGNIFICANT ANTITUMOR-ACTIVITY; MEASLES-VIRUS STRAINS; PHASE-I TRIAL; CLINICAL-TRIAL; GENE-THERAPY; CHECKPOINT BLOCKADE; THYMIDINE KINASE; EXPRESSING IL-12; ONCOLYTIC VIRUS; REOVIRUS;

D O I：

10.1016/j.nec.2020.12.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Glioblastoma multiforme (GBM) represents one of the most challenging malignancies due to many factors including invasiveness, heterogeneity, and an immunosuppressive microenvironment. Current treatment modalities have resulted in only modest effect on outcomes. The development of viral vectors for oncolytic immunovirotherapy and targeted drug delivery represents a promising therapeutic prospect for GBM and other brain tumors. A host of genetically engineered viruses, herpes simplex virus, poliovirus, measles, and others, have been described and are at various stages of clinical development. Herein we provide a review of the advances and current state of oncolytic virotherapy for the targeted treatment of GBM and malignant gliomas. © 2021 Elsevier Inc.

引用

页码：265 / 281

页数：17

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