Perfluorocarbon-Loaded Hollow Bi2Se3 Nanoparticles for Timely Supply of Oxygen under Near-Infrared Light to Enhance the Radiotherapy of Cancer

被引：543

作者：

Song, Guosheng ^{[1
]}

Liang, Chao ^{[1
]}

Yi, Xuan ^{[2
,3
]}

Zhao, Qi ^{[2
,3
]}

Cheng, Liang ^{[1
]}

Yang, Kai ^{[2
,3
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ Suzhou, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[2] Soochow Univ, Coll Med, Sch Radiat Med & Protect, Suzhou 215123, Jiangsu, Peoples R China

[3] Soochow Univ, Coll Med, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Jiangsu, Peoples R China

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 14期

基金：

中国国家自然科学基金;

关键词：

PHOTOTHERMAL ABLATION; PHOTODYNAMIC THERAPY; RADIATION-THERAPY; CATION-EXCHANGE; DRUG-DELIVERY; HYPOXIA; NANOCRYSTALS; SHELL; NANOTHERANOSTICS; NANOMATERIALS;

D O I：

10.1002/adma.201504617

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Hollow Bi2Se3 nanoparticles prepared by a cation exchange method are loaded with perfluorocarbon as an oxygen carrier. With these nanoparticles, a promising concept is demonstrated to enhance radiotherapy by not only using their X-ray-absorbing ability to locally concentrate radiation energy in the tumor, but also employing near-infrared light to trigger burst release of oxygen from the nanoparticles to overcome hypoxia-associated radio-resistance. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2716 / 2723

页数：8

共 59 条

[1] Cation Exchange: A Versatile Tool for Nanomaterials Synthesis [J].

Beberwyck, Brandon J. ;

Surendranath, Yogesh ;

Alivisatos, A. Paul .

JOURNAL OF PHYSICAL CHEMISTRY C, 2013, 117 (39) :19759-19770

[2] GENOMIC INSTABILITY IN CANCER Strategies to improve radiotherapy with targeted drugs [J].

Begg, Adrian C. ;

Stewart, Fiona A. ;

Vens, Conchita .

NATURE REVIEWS CANCER, 2011, 11 (04) :239-253

[3] A Versatile Nanotheranostic Agent for Efficient Dual-Mode Imaging Guided Synergistic Chemo-Thermal Tumor Therapy [J].

Cai, Xiaojun ;

Jia, Xiaoqing ;

Gao, Wei ;

Zhang, Kun ;

Ma, Ming ;

Wang, Shige ;

Zheng, Yuanyi ;

Shi, Jianlin ;

Chen, Hangrong .

ADVANCED FUNCTIONAL MATERIALS, 2015, 25 (17) :2520-2529

[4] The Relationship between Economic Status, Knowledge on Dengue, Risk Perceptions and Practices [J].

Castro, Marta ;

Sanchez, Lizet ;

Perez, Dennis ;

Sebrango, Carlos ;

Shkedy, Ziv ;

Van der Stuyft, Patrick .

PLOS ONE, 2013, 8 (12)

[5] Hyperthermia-Mediated Local Drug Delivery by a Bubble-Generating Liposomal System for Tumor-Specific Chemotherapy [J].

Chen, Ko-Jie ;

Chaung, Er-Yuan ;

Wey, Shiaw-Pyng ;

Lin, Kun-Ju ;

Cheng, Felice ;

Lin, Chia-Chen ;

Liu, Hao-Li ;

Tseng, Hsiang-Wen ;

Liu, Chih-Peng ;

Wei, Ming-Cheng ;

Liu, Chun-Min ;

Sung, Hsing-Wen .

ACS NANO, 2014, 8 (05) :5105-5115

[6] Functional Nanomaterials for Phototherapies of Cancer [J].

Cheng, Liang ;

Wang, Chao ;

Feng, Liangzhu ;

Yang, Kai ;

Liu, Zhuang .

CHEMICAL REVIEWS, 2014, 114 (21) :10869-10939

[7]

Cheng L, 2012, ACS NANO, V6, P5605, DOI [10.1021/nn301539m, 10.1021/nn304719q]

[8] Perfluorodecalin nanocapsule as an oxygen carrier and contrast agent for ultrasound imaging [J].

Chin, L. S. ;

Lim, M. ;

Hung, T. T. ;

Marquis, C. P. ;

Amal, R. .

RSC ADVANCES, 2014, 4 (25) :13052-13060

[9] A pH-Responsive Carrier System that Generates NO Bubbles to Trigger Drug Release and Reverse P-Glycoprotein-Mediated Multidrug Resistance [J].

Chung, Ming-Fan ;

Liu, Hung-Yi ;

Lin, Kun-Ju ;

Chia, Wei-Tso ;

Sung, Hsing-Wen .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2015, 54 (34) :9890-9893

[10] INFLUENCE OF OXYGEN TENSION ON X-RAY-INDUCED CHROMOSOMAL DAMAGE IN EHRLICH ASCITES TUMOR CELLS IRRADIATED INVITRO AND INVIVO [J].

DESCHNER, EE ;

GRAY, LH .

RADIATION RESEARCH, 1959, 11 (01) :115-146

← 1 2 3 4 5 6 →