Missing pieces in the Parkinson's disease puzzle

被引：543

作者：

Obeso, Jose A. ^{[1
,2
,3
]}

Rodriguez-Oroz, Maria C. ^{[1
,2
,3
]}

Goetz, Christopher G. ^{[4
]}

Marin, Concepcion ^{[3
,5
,6
]}

Kordower, Jeffrey H. ^{[4
]}

Rodriguez, Manuel ^{[3
,7
,8
]}

Hirsch, Etienne C. ^{[9
]}

Farrer, Matthew ^{[10
]}

Schapira, Anthony H. V. ^{[11
]}

Halliday, Glenda ^{[12
,13
]}

机构：

[1] Clin Univ, Dept Neurol, Pamplona, Spain

[2] Ctr Appl Med Res, Med Sch Navarra, Ctr Neurosci, Pamplona, Spain

[3] Inst Salud Carlos III, Minist Invest & Ciencias, Ctr Invest Biomed Red Sobre Enfermedades Neurodeg, Madrid, Spain

[4] Rush Univ, Dept Neurol Sci, Med Ctr, Chicago, IL 60612 USA

[5] Univ Barcelona, Lab Neurol Expt, Area Neurociencies, Inst Invest Biomed August Pi I Sunyer, Barcelona, Spain

[6] CIBERNED, Barcelona, Spain

[7] Univ La Laguna, Dept Fisiol, Fac Med, Tenerife, Spain

[8] CIBERNED, Tenerife, Spain

[9] Univ Paris 06, Ctr Rech, Inst Cerveau & Moelle Epiniere, Paris, France

[10] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[11] Univ Dept Clin Neurosci, Inst Neurol, London, England

[12] Prince Wales Med Res Inst, Sydney, NSW, Australia

[13] Univ New S Wales, Sydney, NSW, Australia

来源：

NATURE MEDICINE | 2010年 / 16卷 / 06期

关键词：

GENOME-WIDE ASSOCIATION; ALPHA-SYNUCLEIN; SUBSTANTIA-NIGRA; DOPAMINERGIC-NEURONS; GENE-THERAPY; DOUBLE-BLIND; GLUCOCEREBROSIDASE MUTATIONS; CONTROLLED-TRIAL; FUTURE-RESEARCH; RISK-FACTORS;

D O I：

10.1038/nm.2165

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Parkinson's disease is a neurodegenerative process characterized by numerous motor and nonmotor clinical manifestations for which effective, mechanism-based treatments remain elusive. Here we discuss a series of critical issues that we think researchers need to address to stand a better chance of solving the different challenges posed by this pathology.

引用

页码：653 / 661

页数：9

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