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Clostridium Difficile Infection Worsen Outcome of Hospitalized Patients with Inflammatory Bowel Disease
被引:53
作者:
Zhang, Ting
[1
]
Lin, Qian-Yun
[1
]
Fei, Jia-Xi
[1
]
Zhang, Yan
[1
]
Lin, Min-Yi
[2
]
Jiang, Shuang-Hong
[1
]
Wang, Pu
[1
]
Chen, Ye
[1
]
机构:
[1] Southern Med Univ, Nanfang Hosp, State Key Lab Organ Failure Res, Dept Gastroenterol, Guangzhou 510515, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 5, Infect Dis Ctr, Zhuhai 519000, Peoples R China
来源:
SCIENTIFIC REPORTS
|
2016年
/
6卷
基金:
中国国家自然科学基金;
国家高技术研究发展计划(863计划);
关键词:
TRIOSE PHOSPHATE ISOMERASE;
CROHNS-DISEASE;
TOXIN-B;
INFLIXIMAB;
RISK;
GUIDELINES;
EPIDEMIOLOGY;
PREVALENCE;
MANAGEMENT;
MORTALITY;
D O I:
10.1038/srep29791
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
The prevalence of Clostridium difficile infection (CDI) in patients suffering from inflammatory bowel disease (IBD) has increased rapidly over the past several decades in North America and Europe. However, the exact global epidemiology remains unclear because of insufficient data from developing countries. A total of 646 hospitalized adult IBD patients were enrolled; and their fresh stool specimens were obtained and used for Clostridium difficile detection. The incidence of CDI in Crohn's disease (CD) patients (12.7%) was significantly lower than that in Ulcerative disease (UC) patients (19.3%). Among the toxin types, A(+)B(+) strain was the most common. Length of stay, hospitalization frequency and bowel surgery rate were significantly higher in the CDI than in the non-CDI group in CD or UC patients. More patients in CDI-CD group were still in active and even clinical moderate or severe CD stage than non-CDI-CD group after 2 years of following-up. Fistula, antibiotics and infliximab usage likely increased the CDI rate in CD patients, Infliximab treatment was considered a risk factor in UC patients. CDI is an exacerbating public health issue that may influence IBD course, increase expenditures, and delay the remission of IBD patients. IBD patients with CDI require urgent attention.
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页数:8
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