N-Heterocyclic Carbene-Catalyzed Cascade Reaction Involving the Hydroacylation of Unactivated Alkynes

被引：204

作者：

Biju, Akkattu T. ^{[1
]}

Wurz, Nathalie E. ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 17期

关键词：

INTRAMOLECULAR STETTER REACTION; ACTIVATED DOUBLE-BONDS; GAMMA-BUTYROLACTONES; ALPHA; BETA-UNSATURATED ALDEHYDES; BENZOIN CONDENSATION; CONJUGATE UMPOLUNG; DIRECT ANNULATIONS; EFFICIENT; ENALS; HYDROAMINATION;

D O I：

10.1021/ja102130s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The N-heterocyclic carbene (NHC)-catalyzed hydroacylation of unactivated alkynes to provide alpha,beta-unsaturated ketones is reported. In addition, a rare case of an efficient and selective dually NHC-catalyzed cascade reaction involving the hydroacylation of alkynes and a subsequent intermolecular Stetter reaction allows the formation of chromanones containing a 1,4-diketone moiety.

引用

页码：5970 / +

页数：3

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