In situ NMR study of asymmetric borane reduction reaction - an abnormal factor in the temperature effect on the bis-oxazaborolidine catalyst and the relationship between the catalyst structure and selectivity

被引：13

作者：

Zhao, JK

Bao, XH ^{[1
]}

Liu, XM

Wan, BS

Han, XW

Yang, CG

Hang, JF

Feng, Y

Jiang, B

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 16期

关键词：

D O I：

10.1016/S0957-4166(00)00306-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The relationship between the structure of the catalyst and the selectivity in the asymmetric borane reduction reaction of prochiral ketones is discussed. The variation of the catalyst itself at low temperature is observed by the in situ NMR method and the origin of the temperature effect of the reaction is proposed. It is concluded that the amount of the effective component of the catalyst present has an important effect on the enantioselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3351 / 3359

页数：9

共 12 条

[1] ENANTIOSELECTIVE REDUCTION OF KETONES WITH BORANE, CATALYZED BY (S)-(-)-PROLINE OR (S)-(+)-PROLINOL [J].