Bevacizumab for optic pathway glioma with worsening visual field in absence of imaging progression: 2 case reports and literature review

被引：15

作者：

Yamasaki, Fumiyuki ^{[1
]}

Takano, Motoki ^{[1
]}

Yonezawa, Ushio ^{[1
]}

Taguchi, Akira ^{[1
]}

Kolakshyapati, Manish ^{[1
,2
]}

Okumichi, Hideaki ^{[3
]}

Kiuchi, Yoshiaki ^{[3
]}

Kurisu, Kaoru ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Neurosurg, Grad Sch Biomed & Hlth Sci, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan

[2] B&B Hosp, Dept Neurosci, Gwarko, Lalitpur, Nepal

[3] Hiroshima Univ, Dept Ophthalmol, Grad Sch Biomed & Hlth Sci, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348551, Japan

来源：

CHILDS NERVOUS SYSTEM | 2020年 / 36卷 / 03期

关键词：

Optic pathway glioma; Bevacizumab; Visual field; COLORECTAL-CANCER; CHILDREN; CHEMOTHERAPY; RECURRENT; HYPERTENSION; VINCRISTINE; CARBOPLATIN;

D O I：

10.1007/s00381-019-04407-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Children with optic pathway gliomas (OPGs) frequently suffer from problems of visual function resulting from tumors. Previous reports showed that bevacizumab improved visual function in patients with OPG via tumor response to treatment. In these two case reports, we show that bevacizumab improved visual field without tumor response as seen in imaging. Both, a 10-year-old girl and a 6-year-old boy, had previous history of treatment with platinum-based chemotherapy. They had visual deterioration without tumor progression on MR imaging. Bevacizumab effectively and immediately improved visual field in both patients without imaging response of OPG. We emphasize that bevacizumab should be considered for patients with OPGs having visual deterioration without tumor progression.

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收藏

页码：635 / 639

页数：5

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