Supramolecular engineering of hydrogels for drug delivery

被引:257
作者
Bernhard, Stephane [1 ]
Tibbitt, Mark W. [1 ]
机构
[1] Swiss Fed Inst Technol, Macromol Engn Lab, Dept Mech & Proc Engn, CH-8092 Zurich, Switzerland
基金
瑞士国家科学基金会;
关键词
Supramolecular hydrogel; Shear-thinning; In situ gelation; Self-assembly; Controlled release; Drug-matrix affinity; SELF-HEALING HYDROGELS; HYALURONIC-ACID; INJECTABLE HYDROGEL; CONTROLLED-RELEASE; ALPHA-CYCLODEXTRIN; OSTEOGENIC DIFFERENTIATION; NANOCOMPOSITE HYDROGELS; NETWORK PROPERTIES; BETA-CYCLODEXTRIN; SUSTAINED-RELEASE;
D O I
10.1016/j.addr.2021.02.002
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Supramolecular binding motifs are increasingly employed in the design of biomaterials. The ability to rationally engineer specific yet reversible associations into polymer networks with supramolecular chemistry enables injectable or sprayable hydrogels that can be applied via minimally invasive administration. In this review, we highlight two main areas where supramolecular binding motifs are being used in the design of drug delivery systems: engineering network mechanics and tailoring drug-material affinity. Throughout, we highlight many of the established and emerging chemistries or binding motifs that are useful for the design of supramolecular hydrogels for drug delivery applications. (C) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
引用
收藏
页码:240 / 256
页数:17
相关论文
共 194 条
[1]   Antitumor Photodynamic Therapy Based on Dipeptide Fibrous Hydrogels with Incorporation of Photosensitive Drugs [J].
Abbas, Manzar ;
Xing, Ruirui ;
Zhang, Ning ;
Zou, Qianli ;
Yan, Xuehai .
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2018, 4 (06) :2046-2052
[2]   Injectable shear-thinning hydrogels for delivering osteogenic and angiogenic cells and growth factors [J].
Alarcin, Emine ;
Lee, Tae Yong ;
Karuthedom, Sobha ;
Mohammadi, Marzieh ;
Brennan, Meadhbh A. ;
Lee, Dong Hoon ;
Marrella, Alessandra ;
Zhang, Jin ;
Syla, Denata ;
Zhang, Yu Shrike ;
Khademhosseini, Ali ;
Jang, Hae Lin .
BIOMATERIALS SCIENCE, 2018, 6 (06) :1604-1615
[3]   Solute diffusion within hydrogels. Mechanisms and models [J].
Amsden, B .
MACROMOLECULES, 1998, 31 (23) :8382-8395
[4]   Foreign body reaction to biomaterials [J].
Anderson, James M. ;
Rodriguez, Analiz ;
Chang, David T. .
SEMINARS IN IMMUNOLOGY, 2008, 20 (02) :86-100
[5]  
[Anonymous], 2015, ARTERIOSCL THROM VAS
[6]   Exploiting Electrostatic Interactions in Polymer-Nanoparticle Hydrogels [J].
Appel, Eric A. ;
Tibbitt, Mark W. ;
Greer, Jessica M. ;
Fenton, Owen S. ;
Kreuels, Klaus ;
Anderson, Daniel G. ;
Langer, Robert .
ACS MACRO LETTERS, 2015, 4 (08) :848-852
[7]   Self-assembled hydrogels utilizing polymer-nanoparticle interactions [J].
Appel, Eric A. ;
Tibbitt, Mark W. ;
Webber, Matthew J. ;
Mattix, Bradley A. ;
Veiseh, Omid ;
Langer, Robert .
NATURE COMMUNICATIONS, 2015, 6
[8]   The control of cargo release from physically crosslinked hydrogels by crosslink dynamics [J].
Appel, Eric A. ;
Forster, Rebecca A. ;
Rowland, Matthew J. ;
Scherman, Oren A. .
BIOMATERIALS, 2014, 35 (37) :9897-9903
[9]   Supramolecular polymeric hydrogels [J].
Appel, Eric A. ;
del Barrio, Jesus ;
Loh, Xian Jun ;
Scherman, Oren A. .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (18) :6195-6214
[10]   Sustained release of proteins from high water content supramolecular polymer hydrogels [J].
Appel, Eric A. ;
Loh, Xian Jun ;
Jones, Samuel T. ;
Dreiss, Cecile A. ;
Scherman, Oren A. .
BIOMATERIALS, 2012, 33 (18) :4646-4652