Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of Potential

被引：37

作者：

Khattar, Shivani ^{[1
]}

Khan, Sauban Ahmed ^{[2
]}

Zaidi, Syed Amir Azam ^{[2
]}

Darvishikolour, Mahdi ^{[2
]}

Farooq, Uzma ^{[1
]}

Naseef, Punnoth Poonkuzhi ^{[3
]}

Kurunian, Mohamed Saheer ^{[4
]}

Khan, Mohammed Zaafar ^{[2
]}

Shamim, Athar ^{[1
]}

Khan, Mohd Masih Uzzaman ^{[5
]}

Iqbal, Zeenat ^{[1
]}

Mirza, Mohd Aamir ^{[1
]}

机构：

[1] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut, New Delhi 110062, India

[2] Jamia Hamdard, Sch Pharmaceut Educ & Res, New Delhi 110062, India

[3] Moulana Coll Pharm, Dept Pharmaceut, Perinthalmanna 679321, Kerala, India

[4] King Khalid Univ, Coll Appl Med Sci, Dept Dent Technol, Abha 61421, Saudi Arabia

[5] Qassim Univ, Unaizah Coll Pharm, Dept Pharmaceut Chem & Pharmacognosy, Unaizah 51911, Saudi Arabia

来源：

PHARMACEUTICALS | 2022年 / 15卷 / 08期

关键词：

neuroprotective; anti-thrombogenic; antioxidants; cardioprotective; carcinogenic and anti-aging; FATTY LIVER-DISEASE; TRANS-RESVERATROL; CLINICAL-TRIAL; SERUM-ALBUMIN; RED WINE; CANCER; PREVENTION; ANTIOXIDANT; BIOAVAILABILITY; PLASMA;

D O I：

10.3390/ph15080957

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Resveratrol (RVT) is a well known phyto-chemical and is widely used in dietary supplements and botanical products. It shows a wide range of pharmacological/beneficial effects. Therefore, it can be a potential candidate to be developed as phyto-pharmaceutical. Multiple diseases are reported to be treated by the therapeutic effect of RVT since it has antioxidant, anti-cancer activity and anti-inflammatory activities. It also has a major role in diabetes, arthritis, cardiac disorder and platelet aggregation etc. The major requirements are establishments regarding safety, efficacy profile and physicochemical characterization. As it is already being consumed in variable maximum daily dose, there should not be a major safety concern but the dose needs to be established for different indications. Clinical trials are also being reported in different parts of the world. Physicochemical properties of the moiety are also well reported. Moreover, due to its beneficial effect on health it leads to the development of some intellectual property in the form of patents.

引用

页数：32