HSPA8/HSC70 in Immune Disorders: A Molecular Rheostat that Adjusts Chaperone-Mediated Autophagy Substrates

被引：99

作者：

Bonam, Srinivasa Reddy ^{[1
,2
]}

Ruff, Marc ^{[3
]}

Muller, Sylviane ^{[1
,2
,4
,5
]}

机构：

[1] Univ Strasbourg, CNRS, Neuroimmunol & Peptide Therapy Biotechnol & Cell, F-67412 Illkirch Graffenstaden, France

[2] Lab Excellence Medalis, F-67000 Strasbourg, France

[3] Inst Genet & Biol Mol & Cellulaire, Biol Struct Integrat, F-67404 Strasbourg, France

[4] USIAS, F-67000 Strasbourg, France

[5] Strasbourg Univ, FMTS, OMICARE, FHU, F-67000 Strasbourg, France

来源：

CELLS | 2019年 / 8卷 / 08期

关键词：

chaperone-mediated autophagy; HSPA8; HSC70; lysosomes; pharmacological regulators; P140; autoimmune diseases; systemic lupus erythematosus; MHC CLASS-II; HEAT-SHOCK PROTEINS; ATPASE ACTIVITY; IMMUNOSUPPRESSANT DEOXYSPERGUALIN; THERAPEUTIC PEPTIDE; ANTIGEN TRAFFICKING; EPIGENETIC CONTROL; 70; HSC70; HSP70; HEAT-SHOCK-PROTEIN-70;

D O I：

10.3390/cells8080849

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It plays a crucial role in protein quality control, ensuring the correct folding and re-folding of selected proteins, and controlling the elimination of abnormally-folded conformers and of proteins daily produced in excess in our cells. HSPA8 is a crucial molecular regulator of chaperone-mediated autophagy, as a detector of substrates that will be processed by this specialized autophagy pathway. In this review, we shortly summarize its structure and overall functions, dissect its implication in immune disorders, and list the known pharmacological tools that modulate its functions. We also exemplify the interest of targeting HSPA8 to regulate pathological immune dysfunctions.

引用

页数：26

共 150 条

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