Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats

被引：73

作者：

Fisher, K

Coderre, TJ

机构：

[1] Clin Res Inst Montreal, Pain Mechanisms Lab, Montreal, PQ H2W 1R7, Canada

[2] McGill Univ, Dept Psychol, Montreal, PQ, Canada

[3] Univ Montreal, Ctr Rech Sci Neurol, Montreal, PQ H3C 3J7, Canada

[4] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

来源：

NEUROREPORT | 1998年 / 9卷 / 06期

关键词：

allodynia; dihydroxyphenylglycine; DHPG; hyperalgesia; metabotropic glutamate receptors; mGluR; nociception;

D O I：

10.1097/00001756-199804200-00038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the role of Group I mGluRs in allodynia and hyperalgesia, we examined the behavioural responses of rats to noxious and non-noxious mechanical and thermal stimuli following intrathecal (i.t.) treatment (25 nmol) with the selective mGluR(1/5) agonist, (RS)-dihydroxyphenylglycine ((RS)-DHPG). (RS)-DHPG administration produced a persistent decrease in response latency on a 48 degrees C hotplate, a reduction in the 50% response threshold to von Frey hairs, and an increase in responses to a tail pinch. These data suggest that activation of spinal mGluR(1/5) receptors plays a role in the development of persistent allodynia and hyperalgesia associated with tissue or nerve injury. (C) 1998 Rapid Science Ltd.

引用

页码：1169 / 1172

页数：4

共 17 条

[1]

BLEAKMAN D, 1992, MOL PHARMACOL, V42, P192

[2] PHARMACOLOGY OF METABOTROPIC GLUTAMATE RECEPTOR-MEDIATED ENHANCEMENT OF RESPONSES TO EXCITATORY AND INHIBITORY AMINO-ACIDS ON RAT SPINAL NEURONS IN-VIVO [J].