Autocrine and paracrine regulatory functions of platelet serotonin

被引：62
作者：
Mammadova-Bach, Elmina [1 ,2 ]
Mauler, Maximilian [3 ]
Braun, Attila [1 ,2 ]
Duerschmied, Daniel [3 ]
机构：
[1] Univ Hosp, Inst Expt Biomed, Wurzburg, Germany
[2] Rudolf Virchow Ctr, Wurzburg, Germany
[3] Univ Freiburg, Fac Med, Dept Cardiol & Angiol 1, Heart Ctr, Freiburg, Germany
来源：
PLATELETS | 2018年 / 29卷 / 06期
关键词：
Immune functions; platelet serotonin; signaling; tryptophan hydroxylase; PROTEIN-KINASE-C; REUPTAKE INHIBITORS; DEPRESSED-PATIENTS; BRONCHIAL-ASTHMA; ISCHEMIC-STROKE; DOUBLE-BLIND; IN-VIVO; TRANSPORTER; ANTIDEPRESSANTS; PLASMA;
D O I：
10.1080/09537104.2018.1478072
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Platelets serotonin (5-hydroxytrytamine, 5-HT) uptake and storage in dense granules is tightly regulated by the serotonergic transport system in the blood. Several 5-HT transporters (5-HTTs) have been identified in the vasculature and blood cells, beyond them 5-HTT is the major 5-HT transporter in platelets. Abnormal 5-HT concentrations in the blood plasma or increased platelet 5-HT uptake or abnormal release contribute to the development of various diseases in the vasculature. Consequently, several clinical trials suggested the positive therapeutic effects of 5-HTT blockade in the circulation. Inhibition of 5-HT strongly attenuates autocrine and paracrine functions of platelets, influencing platelet aggregation, vascular contraction, permeability, tissue repair, wound healing, immunity and cancer. Here, we highlight the current state of basic biological research regarding the hemostatic and non-hemostatic functions of platelet-derived 5-HT in normal and disease conditions. We also describe the physiological consequences of targeting platelet 5-HT functions in thrombosis, stroke, inflammation and cancer to overcome common health problems.
引用
收藏
页码：541 / 548
页数：8
相关论文
共 97 条
[31]   Platelet granule secretion continuously prevents intratumor hemorrhage [J].
Ho-Tin-Noe, Benoit ;
Goerge, Tobias ;
Cifuni, Stephen M. ;
Duerschmied, Daniel ;
Wagner, Denisa D. .
CANCER RESEARCH, 2008, 68 (16) :6851-6858
[32]  
HOYER D, 1994, PHARMACOL REV, V46, P157
[33]   SEROTONIN UP-REGULATES MITOGEN-STIMULATED B-LYMPHOCYTE PROLIFERATION THROUGH 5-HT1A RECEPTORS [J].
IKEN, K ;
CHHENG, S ;
FARGIN, A ;
GOULET, AC ;
KOUASSI, E .
CELLULAR IMMUNOLOGY, 1995, 163 (01) :1-9
[34]   Use of Selective Serotonin Reuptake Inhibitors and Risk of Upper Gastrointestinal Bleeding: A Systematic Review and Meta-analysis [J].
Jiang, Hai-Yin ;
Chen, Hua-Zhong ;
Hu, Xin-Jun ;
Yu, Zheng-He ;
Yang, Wei ;
Deng, Min ;
Zhang, Yong-Hua ;
Ruan, Bing .
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2015, 13 (01) :42-+
[35]   PULMONARY NEUROENDOCRINE CELLS - THEIR SECRETORY PRODUCTS AND THEIR POTENTIAL ROLES IN HEALTH AND CHRONIC LUNG-DISEASE IN INFANCY [J].
JOHNSON, DE ;
GEORGIEFF, MK .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1989, 140 (06) :1807-1812
[36]   Increase of urinary 5-hydroxyindoleacetic acid excretion but not serum chromogranin A following over-the-counter 5-hydroxytryptophan intake [J].
Joy, Tisha ;
Walsh, Grace R. N. ;
Tokmakejian, Sonya ;
Van Uum, Stan H. M. .
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2008, 22 (01) :49-53
[37]   The global burden of mental disorders: An update from the WHO World Mental Health (WMH) Surveys [J].
Kessler, Ronald C. ;
Aguilar-Gaxiola, Sergio ;
Alonso, Jordi ;
Chatterji, Somnath ;
Lee, Sing ;
Ormel, Johan ;
Uestuen, T. Bedirhan ;
Wang, Philip S. .
EPIDEMIOLOGIA E PSICHIATRIA SOCIALE-AN INTERNATIONAL JOURNAL FOR EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES, 2009, 18 (01) :23-33
[38]   Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function [J].
Keszthelyi, D. ;
Troost, F. J. ;
Masclee, A. A. M. .
NEUROGASTROENTEROLOGY AND MOTILITY, 2009, 21 (12) :1239-1249
[39]   Serotonin regulates pancreatic beta cell mass during pregnancy [J].
Kim, Hail ;
Toyofuku, Yukiko ;
Lynn, Francis C. ;
Chak, Eric ;
Uchida, Toyoyoshi ;
Mizukami, Hiroki ;
Fujitani, Yoshio ;
Kawamori, Ryuzo ;
Miyatsuka, Takeshi ;
Kosaka, Yasuhiro ;
Yang, Katherine ;
Honig, Gerard ;
van der Hart, Marieke ;
Kishimoto, Nina ;
Wang, Juehu ;
Yagihashi, Soroku ;
Tecott, Laurence H. ;
Watada, Hirotaka ;
German, Michael S. .
NATURE MEDICINE, 2010, 16 (07) :804-U106
[40]   Elevated platelet factor 4 and beta-thromboglobulin plasma levels in depressed patients with ischemic heart disease [J].
LaghrissiThode, F ;
Wagner, WR ;
Pollock, BG ;
Johnson, PC ;
Finkel, MS .
BIOLOGICAL PSYCHIATRY, 1997, 42 (04) :290-295
12345678910