Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus

被引：363

作者：

Evers, Andrea W. M. ^{[1
]}

Colloca, Luana ^{[2
,3
]}

Blease, Charlotte ^{[4
]}

Annoni, Marco ^{[5
]}

Atlas, Lauren Y. ^{[6
]}

Benedetti, Fabrizio ^{[7
]}

Bingel, Ulrike ^{[8
]}

Buechel, Christian ^{[9
]}

Carvalho, Claudia ^{[10
]}

Colagiuri, Ben ^{[11
]}

Crum, Alia J. ^{[12
]}

Enck, Paul ^{[13
]}

Gaab, Jens ^{[14
]}

Geers, Andrew L. ^{[15
]}

Howick, Jeremy ^{[16
]}

Jensen, Karin B. ^{[17
]}

Kirsch, Irving ^{[18
]}

Meissner, Karin ^{[19
]}

Napadow, Vitaly ^{[20
]}

Peerdeman, Kaya J. ^{[1
]}

Raz, Amir ^{[21
,22
,23
]}

Rief, Winfried ^{[24
]}

Vase, Lene ^{[25
]}

Wager, Tor D. ^{[26
]}

Wampold, Bruce E. ^{[27
,28
]}

Weimer, Katja ^{[29
]}

Wiech, Katja ^{[30
]}

Kaptchuk, Ted J. ^{[18
]}

Klinger, Regine ^{[31
]}

Kelley, John M. ^{[18
]}

机构：

[1] Leiden Univ, Inst Psychol, Hlth Med & Neuropsychol Unit, POB 9555, NL-2300 RB Leiden, Netherlands

[2] Univ Maryland, Sch Nursing & Med, Dept Pain Translat Symptoms Sci, Baltimore, MD 21201 USA

[3] Univ Maryland, Sch Nursing & Med, Dept Anaesthesiol, Baltimore, MD 21201 USA

[4] Beth Israel Deaconess Med Ctr, Gen Med & Primary Care, Boston, MA 02215 USA

[5] CNR, Inst Biomed Technol, Rome, Italy

[6] NIH, Sect Affect Neurosci & Pain, Bldg 10, Bethesda, MD 20892 USA

[7] Univ Turin, Sch Med, Physiol & Neurosci, Turin, Italy

[8] Univ Hosp Essen, Dept Neurol, Essen, Germany

[9] Univ Med Ctr Hamburg Eppendorf, Dept Syst Neurosci, Hamburg, Germany

[10] Inst Univ Ciencias Psicol, Dept Clin & Hlth Psychol, Lisbon, Portugal

[11] Univ Sydney, Sch Psychol, Sydney, NSW, Australia

[12] Stanford Univ, Dept Psychol, Stanford, CA USA

[13] Univ Hosp Tubingen, Dept Psychosomat Med & Psychotherapy, Tubingen, Germany

[14] Univ Basel, Fac Psychol, Basel, Switzerland

[15] Univ Toledo, Dept Psychol, Toledo, OH 43606 USA

[16] Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England

[17] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[18] Beth Israel Deaconess Med Ctr, Program Placebo Studies, Boston, MA 02215 USA

[19] Univ Appl Sci, Div Hlth Promot, Coburg, Germany

[20] Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA

[21] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[22] McGill Univ, Dept Neurol, Montreal, PQ, Canada

[23] McGill Univ, Dept Neurosurg, Montreal, PQ, Canada

[24] Philipps Univ Marburg, Dept Clin Psychol & Psychotherapy, Marburg, Germany

[25] Aarhus Univ, Dept Psychol & Behav Sci, Aarhus, Denmark

[26] Univ Colorado, Dept Psychol & Neurosci, Boulder, CO 80309 USA

[27] Univ Wisconsin, Dept Counseling Psychol, Madison, WI USA

[28] Modum Bad Psychiat Ctr, Vikersund, Norway

[29] Univ Hosp Ulm, Clin Psychosomat Med & Psychotherapy, Ulm, Germany

[30] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[31] Univ Med Ctr Hamburg Eppendorf, Ctr Anesthesiol & Intens Care Med, Hamburg, Germany

来源：

PSYCHOTHERAPY AND PSYCHOSOMATICS | 2018年 / 87卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Placebo effect; Nocebo effect; Patient's expectancies; Clinical practice; Patient-clinician communication; Evidence-based ethical recommendations; RANDOMIZED CONTROLLED-TRIAL; OPEN-LABEL PLACEBO; MAJOR DEPRESSIVE DISORDER; LOW-BACK-PAIN; DECEPTION; INTERVENTIONS; COMMUNICATION; METAANALYSIS; MECHANISMS; ANALGESIA;

D O I：

10.1159/000490354

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Background: Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment or as part of active treatments and are due to psychobiological mechanisms such as expectancies of the patient. Placebo and nocebo studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling the neurobiological, behavioural and clinical underpinnings of these phenomena in a broad variety of medical conditions. As a consequence, there is an increasing demand from health professionals to develop expert recommendations about evidence-based and ethical use of placebo and nocebo effects for clinical practice. Methods: A survey and interdisciplinary expert meeting by invitation was organized as part of the 1st Society for Interdisciplinary Placebo Studies (SIPS) conference in 2017. Twenty-nine internationally recognized placebo researchers participated. Results: There was consensus that maximizing placebo effects and minimizing nocebo effects should lead to better treatment outcomes with fewer side effects. Experts particularly agreed on the importance of informing patients about placebo and nocebo effects and training health professionals in patient-clinician communication to maximize placebo and minimize nocebo effects. Conclusions: The current paper forms a first step towards developing evidence-based and ethical recommendations about the implications of placebo and nocebo research for medical practice, based on the current state of evidence and the consensus of experts. Future research might focus on how to implement these recommendations, including how to optimize conditions for educating patients about placebo and nocebo effects and providing training for the implementation in clinical practice. (C) 2018 S. Karger AG, Basel

引用

页码：204 / 210

页数：7

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