Human neutrophil α-defensin 4 inhibits HIV-1 infection in vitro

被引：83
|
作者：
Wu, ZB
Cocchi, F
Gentles, D
Ericksen, B
Lubkowski, J
DeVico, A
Lehrer, RI
Lu, WY
机构：
[1] Univ Maryland, Inst Biotechnol, Inst Human Virol, Baltimore, MD 21201 USA
[2] NCI, Macromol Assembly Struct & Cell Signaling Sect, Frederick, MD 21702 USA
[3] Univ Calif Los Angeles, Dept Med, Los Angeles, CA 90095 USA
来源：
FEBS LETTERS | 2005年 / 579卷 / 01期
关键词：
HIV-1; defensin; CD4; gp120; surface plasmon resonance; peptide synthesis;
D O I：
10.1016/j.febslet.2004.11.062
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Human neutrophil alpha-defensin 4 (HNP4) is more effective than HNP1-3 in protecting human peripheral blood mononuclear cells from infection by both X4 and R5 HIV-1 strains. HNP4 binds to both CD4 and gp120 approximately two orders of magnitude weaker than does HNP1, and is less effectively sequestered by glycosylated serum proteins than HNP1. These results suggest that the HIV-1 inhibition by HNP4 stems at least partially from a unique and lectin-independent property of HNP4 with CD4 and/or gp120. Our finding identifies an anti-HIV-1 property of HNP4 and may have implications in the development of new antiviral agents for AIDS therapy. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：162 / 166
页数：5
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