Inhibitors of Src tyrosine kinase: The preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines

被引：68
作者：
Wang, YD [1 ]
Miller, K [1 ]
Boschelli, DH [1 ]
Ye, F [1 ]
Wu, BQ [1 ]
Floyd, MB [1 ]
Powell, DW [1 ]
Wissner, A [1 ]
Weber, JM [1 ]
Boschelli, F [1 ]
机构：
[1] Wyeth Ayerst Res, Chem Sci & Oncol, Pearl River, NY 10965 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2000年 / 10卷 / 21期
关键词：
D O I：
10.1016/S0960-894X(00)00493-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Src is a nonreceptor tyrosine kinase involved in signaling pathways that control proliferation, migration, and angiogenesis. Increased Src expression and activity are associated with an increase in tumor malignancy and poor prognosis. Several quinolines and quinazolines were identified as potent and selective inhibitors of Src kinase activity. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2477 / 2480
页数：4
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