Molecular Insights into Crimean-Congo Hemorrhagic Fever Virus

被引：102

作者：

Zivcec, Marko ^{[1
]}

Scholte, Florine E. M. ^{[1
]}

Spiropoulou, Christina F. ^{[1
]}

Spengler, Jessica R. ^{[1
]}

Bergeron, Eric ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Div High Consequence Pathogens & Pathol, Viral Special Pathogens Branch, Atlanta, GA 30333 USA

来源：

VIRUSES-BASEL | 2016年 / 8卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Crimean-Congo hemorrhagic fever; viral hemorrhagic fever; reverse genetics; pathogenesis; tick-borne virus; RIFT-VALLEY FEVER; STIMULATED GENE 15; VIRAL LOAD; NUCLEOCAPSID PROTEIN; HANTAAN VIRUS; CCHF VIRUS; TRANSCRIPTION TERMINATION; CRYSTAL-STRUCTURE; STRUCTURAL BASIS; IMMUNE-RESPONSE;

D O I：

10.3390/v8040106

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication and pathogenesis in the past decade. Here we review the most recent molecular advances in CCHFV-related research, and provide perspectives on future research.

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页数：21

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