A Hybridised Optimisation of an Automated Photochemical Continuous Flow Reactor

被引：14

作者：

Manson, Jamie A. ^{[1
,2
]}

Clayton, Adam D. ^{[1
,2
]}

Nino, Carlos Gonzalez ^{[3
]}

Labes, Ricardo ^{[1
,2
]}

Chamberlain, Thomas W. ^{[1
,2
]}

Blacker, A. John ^{[1
,2
]}

Kapur, Nikil ^{[3
]}

Bourne, Richard A. ^{[1
,2
]}

机构：

[1] Univ Leeds, Sch Chem, Inst Proc Res & Dev, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Leeds, Sch Chem & Proc Engn, Leeds LS2 9JT, W Yorkshire, England

[3] Univ Leeds, Sch Mech Engn, Leeds LS2 9JT, W Yorkshire, England

来源：

CHIMIA | 2019年 / 73卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

Algorithm; Automation; Continuous flow; Photochemistry; Self-optimisation; PHOTOREDOX CATALYSIS; SCALE-UP; CHEMISTRY; STRATEGY; CASCADE; DESIGN;

D O I：

10.2533/chimia.2019.817

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new hybridized algorithm that combines process optimisation with response surface mapping was developed and applied in an automated continuous flow reaction. Moreover, a photochemical cascade CSTR was developed and characterised by chemical actinometry, showing photon flux density of ten times greater than previously reported in batch. The success of the algorithm was then evaluated in the aerobic oxidation of sp(3) C-H bonds using benzophenone as photosensitizer in the newly developed photo reactor.

引用

页码：817 / 822

页数：6

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