Neuroscience of apathy and anhedonia: a transdiagnostic approach

被引:394
作者
Husain, Masud [1 ,2 ]
Roiser, Jonathan P. [3 ]
机构
[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Neurosci, Oxford, England
[2] Univ Oxford, John Radcliffe Hosp, Dept Expt Psychol, Oxford, England
[3] UCL, Inst Cognit Neurosci, London, England
基金
英国惠康基金;
关键词
REWARD PREDICTION ERRORS; GOAL-DIRECTED BEHAVIOR; DORSAL RAPHE NUCLEUS; RATING-SCALE LARS; NEGATIVE SYMPTOMS; PARKINSONS-DISEASE; DECISION-MAKING; BASAL GANGLIA; MOTIVATIONAL FUNCTIONS; ALZHEIMERS-DISEASE;
D O I
10.1038/s41583-018-0029-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The findings suggest that there might be some shared mechanisms between both syndromes. A transdiagnostic approach that cuts across traditional disease boundaries provides a potentially useful means for understanding these conditions.
引用
收藏
页码:470 / 484
页数:15
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