Microbiota-gut-brain axis in the Alzheimer's disease pathology-an overview

被引:36
作者
V. Giridharan, Vijayasree [1 ,3 ]
De Quevedo, Carlos E. Barichello [2 ]
Petronilho, Fabricia [2 ]
机构
[1] Univ Texas Hlth Sci Ctr Houston UTHealth, McGovern Med Sch, Faillace Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA
[2] Univ Southern Santa Catarina UNESC, Grad Program Hlth Sci, Lab Expt Neurol, Criciuma, SC, Brazil
[3] Univ Texas Hlth Sci Ctr Houston, Faillace Dept Psychiat & Behav Sci, 1941 East Rd, Houston, TX 77054 USA
关键词
Microbiota-gut-brain axis; SCFAs; Immune system; Alzheimer?s disease; BIOGENIC-AMINES; METAANALYSIS; BIOMARKERS; PROBIOTICS; INFECTION; BACTERIA; RECEPTOR; MOUSE;
D O I
10.1016/j.neures.2022.05.003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Alzheimer's disease (AD) and related dementias (ADRD) are still a serious global public health concern more than a century after the German neuropathologist and psychiatrist Dr. Aloysius Alzheimer described the first case. The World Health Organization (WHO) estimates that over 50 million people worldwide suffer from dementia, with AD accounting for 60-70% of all cases. In addition, the global dementia epidemic is estimated to affect 82 million individuals by 2030 and 152 million by 2050. Along with genetic factors, environmental factors, and aging also increase the risks of developing neurodegenerative disorders. For example, gut microbiota can serve as non-genetic factors that define a threshold for maintaining a homeostatic balance or developing illnesses. The scientific community has explored and identified that patients with AD often present with dysbiosis of the bowel and dysregulated gastrointestinal (GI) tract. Research describes it as a bidirectional relationship by which the brain communicates with the gut's microbiome through the vagus nerve, immune and neuroimmune systems, enteroendocrine system, neurotransmitters, branched-chain amino acids, short-chain fatty acids (SCFAs), agonists of aryl hydrocarbon receptors (AHRs), bile acids, and the hypothalamic-pituitary-adrenal (HPA) axis. In this narrative review, we explore and clarify the involvement of the microbiota-gut-brain axis in AD pathology.
引用
收藏
页码:17 / 21
页数:5
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共 50 条
[1]   Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease [J].
Agus, Allison ;
Planchais, Julien ;
Sokol, Harry .
CELL HOST & MICROBE, 2018, 23 (06) :716-724
[2]   Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers [J].
Allen, A. P. ;
Hutch, W. ;
Borre, Y. E. ;
Kennedy, P. J. ;
Temko, A. ;
Boylan, G. ;
Murphy, E. ;
Cryan, J. F. ;
Dinan, T. G. ;
Clarke, G. .
TRANSLATIONAL PSYCHIATRY, 2016, 6 :e939-e939
[3]  
Barichello T., 1999, WHAT IS ROLE MICROBI, P2021
[4]   A cerebrospinal fluid biosignature for the diagnosis of Alzheimer's disease [J].
Barichello, Tatiana ;
Giridharan, Vijayasree V. ;
Dal-Pizzol, Felipe .
BRAZILIAN JOURNAL OF PSYCHIATRY, 2019, 41 (06) :467-468
[5]   Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease [J].
Bateman, Randall J. ;
Xiong, Chengjie ;
Benzinger, Tammie L. S. ;
Fagan, Anne M. ;
Goate, Alison ;
Fox, Nick C. ;
Marcus, Daniel S. ;
Cairns, Nigel J. ;
Xie, Xianyun ;
Blazey, Tyler M. ;
Holtzman, David M. ;
Santacruz, Anna ;
Buckles, Virginia ;
Oliver, Angela ;
Moulder, Krista ;
Aisen, Paul S. ;
Ghetti, Bernardino ;
Klunk, William E. ;
McDade, Eric ;
Martins, Ralph N. ;
Masters, Colin L. ;
Mayeux, Richard ;
Ringman, John M. ;
Rossor, Martin N. ;
Schofield, Peter R. ;
Sperling, Reisa A. ;
Salloway, Stephen ;
Morris, John C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (09) :795-804
[6]   Alzheimer's disease and the microbiome [J].
Bhattacharjee, Surjyadipta ;
Lukiw, Walter J. .
FRONTIERS IN CELLULAR NEUROSCIENCE, 2013, 7
[7]   Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin [J].
Borovikova, LV ;
Ivanova, S ;
Zhang, MH ;
Yang, H ;
Botchkina, GI ;
Watkins, LR ;
Wang, HC ;
Abumrad, N ;
Eaton, JW ;
Tracey, KJ .
NATURE, 2000, 405 (6785) :458-462
[8]   Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve [J].
Bravo, Javier A. ;
Forsythe, Paul ;
Chew, Marianne V. ;
Escaravage, Emily ;
Savignac, Helene M. ;
Dinan, Timothy G. ;
Bienenstock, John ;
Cryan, John F. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (38) :16050-16055
[9]  
Chen, NUTR BURBANK ANGEL C, V93, P2022
[10]   Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans [J].
Cirrito, John R. ;
Disabato, Brianne M. ;
Restivo, Jessica L. ;
Verges, Deborah K. ;
Goebel, Whitney D. ;
Sathyan, Anshul ;
Hayreh, Davinder ;
D'Angelo, Gina ;
Benzinger, Tammie ;
Yoon, Hyejin ;
Kim, Jungsu ;
Morris, John C. ;
Mintun, Mark A. ;
Sheline, Yvette I. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (36) :14968-14973