μ opioid receptor knockout in mice:: effects on ligand-induced analgesia and morphine lethality

被引：282

作者：

Loh, HH ^{[1
]}

Liu, HC ^{[1
]}

Cavalli, A ^{[1
]}

Yang, WL ^{[1
]}

Chen, YF ^{[1
]}

Wei, LN ^{[1
]}

机构：

[1] Univ Minnesota, Sch Med, Dept Pharmacol, Minneapolis, MN 55455 USA

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 54卷 / 02期

关键词：

mu opioid receptor; gene-targeting; morphine analgesia; morphine lethality;

D O I：

10.1016/S0169-328X(97)00353-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mu opioid receptor gene (MOR) was mutated in mice by a gene targeting procedure. In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide (M-6-G) and morphine-6-ethereal sulfate (M-6-S), and endomorphin-2, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged. It is concluded that analgesic effects of mu-specific opioid ligands and acute morphine lethality are mediated by the mu receptor. (C) 1998 Elsevier Science B.V.

引用

页码：321 / 326

页数：6

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