Clinical features and prognostic factors of intensive and non-intensive 1014 COVID-19 patients: an experience cohort from Alahsa, Saudi Arabia

被引:29
作者
Alhumaid, Saad [1 ]
Al Mutair, Abbas [2 ,3 ,4 ]
Al Alawi, Zainab [5 ]
Al Salman, Khulud [6 ]
Al Dossary, Nourah [7 ]
Omar, Ahmed [8 ]
Alismail, Mossa [9 ]
Al Ghazal, Ali M. [10 ]
Jubarah, Mahdi Bu [9 ]
Al Shaikh, Hanan [9 ]
Al Mahdi, Maher M. [10 ]
Alsabati, Sarah Y. [11 ]
Philip, Dayas K. [12 ]
Alyousef, Mohammed Y. [13 ]
Al Brahim, Abdulsatar H. [14 ]
Al Athan, Maitham S. [15 ]
Alomran, Salamah A. [14 ]
Ahmed, Hatim S. [15 ]
Al-Shammari, Haifa [16 ]
Elhazmi, Alyaa [17 ]
Rabaan, Ali A. [18 ]
Al-Tawfiq, Jaffar A. [19 ,20 ,21 ]
Al-Omari, Awad [22 ,23 ]
机构
[1] Minist Hlth, Alahsa Hlth Cluster, Adm Pharmaceut Care, Rashdiah St,POB 12944, Alahsa 31982, Saudi Arabia
[2] Almoosa Specialist Hosp, Res Ctr, Alahsa, Saudi Arabia
[3] Univ Wollongong, Sch Nursing, Wollongong, NSW, Australia
[4] Princess NorahBint Abdul Rahman Univ, Coll Nursing, Riyadh, Saudi Arabia
[5] King Faisal Univ, Coll Med, Div Allergy & Immunol, Alahsa, Saudi Arabia
[6] Minist Hlth, Dept Nursing, Al Jaber Hosp Eye Ear Nose & Throat, Al Hufuf, Saudi Arabia
[7] Alomran Gen Hosp, Dept Gen Surg, Alahsa, Saudi Arabia
[8] Alomran Gen Hosp, Internal Med Dept, Alahsa, Saudi Arabia
[9] King Faisal Gen Hosp, Dept Pharm, Alahsa, Saudi Arabia
[10] Prince Saud Bin Jalawi Hosp, Infect Prevent & Control Dept, Alahsa, Saudi Arabia
[11] Matern & Children Hosp, Dept Nursing, Alahsa, Saudi Arabia
[12] Matern & Children Hosp, Nursing Educ Dept, Alahsa, Saudi Arabia
[13] Minist Hlth, Adm Acad Affairs & Res, Alahsa, Saudi Arabia
[14] King Fahad Hofuf Hosp, Dept Pharm, Alahsa, Saudi Arabia
[15] Minist Hlth, Planning & Res Dept, Alahsa, Saudi Arabia
[16] King Saud Med City, Dept Histopathol, Riyadh, Saudi Arabia
[17] Dr Sulaiman Al Habib Med Grp, Intens Care Unit Dept, Riyadh, Saudi Arabia
[18] Johns Hopkins Aramco Healthcare Dhahran, Mol Diagnost Lab, Dhahran, Saudi Arabia
[19] Johns Hopkins Aramco Healthcare, Infect Dis Unit, Specialty Internal Med, Dhahran, Saudi Arabia
[20] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA
[21] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[22] Alfaisal Univ, Coll Med, Riyadh, Saudi Arabia
[23] Dr Sulaiman Al Habib Med Grp, Res Ctr, Riyadh, Saudi Arabia
关键词
Admission; Clinical; Characteristics; COVID-19; ICU; Intensive; Care; Critical; Mortality; Outcomes; SARS-CoV-2; Saudi Arabia; CORONAVIRUS DISEASE 2019; HOSPITALIZED-PATIENTS; X-CHROMOSOME; INFECTION; OUTCOMES;
D O I
10.1186/s40001-021-00517-7
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background COVID-19 is a worldwide pandemic and has placed significant demand for acute and critical care services on hospitals in many countries. Objectives To determine the predictors of severe COVID-19 disease requiring admission to an ICU by comparing patients who were ICU admitted to non-ICU groups. Methods A cohort study was conducted for the laboratory-confirmed COVID-19 patients who were admitted to six Saudi Ministry of Health's hospitals in Alahsa, between March 1, 2020, and July 30, 2020, by reviewing patient's medical records retrospectively. Results This cohort included 1014 patients with an overall mean age of 47.2 +/- 19.3 years and 582 (57%) were males. A total of 205 (20%) of the hospitalized patients were admitted to the ICU. Hypertension, diabetes and obesity were the most common comorbidities in all study patients (27.2, 19.9, and 9%, respectively). The most prevalent symptoms were cough (47.7%), shortness of breath (35.7%) and fever (34.3%). Compared with non-ICU group, ICU patients had older age (p <= 0.0005) and comprised a higher proportion of the current smokers and had higher respiratory rates (p <= 0.0005), and more percentage of body temperatures in the range of 37.3-38.0 degrees C (p >= 0.0005); and had more comorbidities including diabetes (p <= 0.0005), hypertension (p >= 0.0005), obesity (p = 0.048), and sickle cell disease (p = 0.039). There were significant differences between the non-ICU and ICU groups for fever, shortness of breath, cough, fatigue, vomiting, dizziness; elevated white blood cells, neutrophils, alanine aminotransferase and alkaline aminotransferase, lactate dehydrogenase, and ferritin, and decreased hemoglobin; and proportion of abnormal bilateral chest CT images (p < 0.05). Significant differences were also found for multiple treatments (p < 0.05). ICU patients group had a much higher mortality rate than those with non-ICU admission (p <= 0.0005). Conclusion Identifying key clinical characteristics of COVID-19 that predict ICU admission and high mortality can be useful for frontline healthcare providers in making the right clinical decision under time-sensitive and resource-constricted environment.
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