Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E

被引:181
作者
O'Callaghan, CA [1 ]
Tormo, J
Willcox, BE
Braud, VM
Jakobsen, BK
Stuart, DI
McMichael, AJ
Bell, JI
Jones, EY
机构
[1] Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Nuffield Dept Clin Med,Mol Immunol Grp, Oxford OX3 9DS, England
[2] Univ Oxford, Mol Biophys Lab, Oxford OX1 3QU, England
[3] Univ Oxford, Oxford Ctr Mol Sci, Oxford OX1 3QT, England
基金
英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;
关键词
D O I
10.1016/S1097-2765(00)80053-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The crystal structure of the nonclassical human class Ib MHC molecule HLA-E has been determined in complex with a prototypic ligand, the nonamer peptide (VMAPRTVLL), derived from the highly conserved residues 3-11 of the human MHC class la leader sequence. The mode of peptide binding retains some of the standard features observed in MHC class la complexes, but novel features imply that HLA-E has evolved to mediate specific binding to a tightly defined set of almost identical hydrophobic peptides from the highly conserved class I leader sequences. These molecular adaptations make HLA-E a rigorous checkpoint at the cell surface reporting on the integrity of the antigen processing pathway to CD94/NKG2 receptor-bearing natural killer cells.
引用
收藏
页码:531 / 541
页数:11
相关论文
共 49 条
[1]   IDENTIFICATION OF A TAP-DEPENDENT LEADER PEPTIDE RECOGNIZED BY ALLOREACTIVE T-CELLS SPECIFIC FOR A CLASS IB ANTIGEN [J].
ALDRICH, CJ ;
DECLOUX, A ;
WOODS, AS ;
COTTER, RJ ;
SOLOSKI, MJ ;
FORMAN, J .
CELL, 1994, 79 (04) :649-658
[2]   High polymorphism of Mhc-E locus in non-human primates: Alleles with identical exon 2 and 3 are found in two different species [J].
Alvarez, M ;
MartinezLaso, J ;
Varela, P ;
DiazCampos, N ;
GomezCasado, E ;
VargasAlarcon, G ;
GarciaTorre, C ;
ArnaizVillena, A .
TISSUE ANTIGENS, 1997, 49 (02) :160-167
[3]   A FAST ALGORITHM FOR RENDERING SPACE-FILLING MOLECULE PICTURES [J].
BACON, D ;
ANDERSON, WF .
JOURNAL OF MOLECULAR GRAPHICS, 1988, 6 (04) :219-220
[4]   DOWN-REGULATION OF THE CLASS-I HLA HETERODIMER AND BETA-2-MICROGLOBULIN ON THE SURFACE OF CELLS INFECTED WITH CYTOMEGALOVIRUS [J].
BARNES, PD ;
GRUNDY, JE .
JOURNAL OF GENERAL VIROLOGY, 1992, 73 :2395-2403
[5]   STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].
BJORKMAN, PJ ;
SAPER, MA ;
SAMRAOUI, B ;
BENNETT, WS ;
STROMINGER, JL ;
WILEY, DC .
NATURE, 1987, 329 (6139) :506-512
[6]   THE FOREIGN ANTIGEN-BINDING SITE AND T-CELL RECOGNITION REGIONS OF CLASS-I HISTOCOMPATIBILITY ANTIGENS [J].
BJORKMAN, PJ ;
SAPER, MA ;
SAMRAOUI, B ;
BENNETT, WS ;
STROMINGER, JL ;
WILEY, DC .
NATURE, 1987, 329 (6139) :512-518
[7]  
BOYSON JE, 1995, IMMUNOGENETICS, V41, P59
[8]   The human major histocompatibility complex class Ib molecule HLA-E binds signal sequence-derived peptides with primary anchor residues at positions 2 and 9 [J].
Braud, V ;
Jones, EY ;
McMichael, A .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1997, 27 (05) :1164-1169
[9]   TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide [J].
Braud, VM ;
Allan, DSJ ;
Wilson, D ;
McMichael, AJ .
CURRENT BIOLOGY, 1998, 8 (01) :1-10
[10]   HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C [J].
Braud, VM ;
Allan, DSJ ;
O'Callaghan, CA ;
Söderström, K ;
D'Andrea, A ;
Ogg, GS ;
Lazetic, S ;
Young, NT ;
Bell, JI ;
Phillips, JH ;
Lanier, LL ;
McMichael, AJ .
NATURE, 1998, 391 (6669) :795-799