Synthesis and electronic structure of novel Schiff bases Ni/Cu (II) complexes: Evaluation of DNA/serum protein binding by spectroscopic studies

被引：49

作者：

Sedighipoor, Maryam ^{[1
]}

Kianfar, Ali Hossein ^{[1
]}

Mahmood, Wan Ahmad Kamil ^{[2
]}

Azarian, Mohammad Hossein ^{[2
]}

机构：

[1] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran

[2] Univ Sains Malaysia, Sch Chem Sci, Minden 11800, Penang, Malaysia

来源：

POLYHEDRON | 2017年 / 129卷

基金：

美国国家科学基金会;

关键词：

ONNO Schiff base complexes; Crystal structure; DNA binding; BSA binding; Biointeraction of metal Schiff base complexes; LIGAND COPPER(II) COMPLEXES; TRANSITION-METAL-COMPLEXES; DNA-BINDING; CRYSTAL-STRUCTURE; CYTOTOXIC ACTIVITIES; NUCLEASE ACTIVITY; CLEAVAGE; BSA; NICKEL(II); FLUORESCENCE;

D O I：

10.1016/j.poly.2017.03.027

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

[Cu(L)] (1) and [Ni(L)] (2) [L = N-2-hydroxyacetophenon-N'-2-hydroxynaphthaldehyde-1,2 phenylenediimine)], Schiff base complexes have been successfully synthesized. Single crystal X-ray crystallography, Fourier Transform infrared spectroscopy (FT-IR), NMR spectroscopy and elemental analysis (EA) have been used to characterize the complexes. Complex 1 shows unsymmetrical ligand coordination to copper (II) ion in a tetradentate fashion through ONNO donor atoms according to single crystal X-ray patterns. Spectroscopic methods have been used to study the interactions between the synthesized Schiff base complexes and Calf Thymus DNA (CT-DNA) and Bovine Serum Albumin (BSA) under physiological conditions. UV-vis absorption, fluorescence, and circular dichroism (CD) spectroscopy and thermal denaturation measurements were used in the investigation of DNA binding properties of these two complexes. The two complexes can bind to Calf Thymus DNA (CT-DNA) via an intercalative mode and complex 1 exhibits stronger interaction with CT-DNA compared with complex 2 based on the results. In addition, both compounds interact with BSA to change its microenvironment during interaction. Cu (II) complex has more affinity for BSA based on the quenching (K-sv) and binding constant (K-b) values of both compounds with BSA. Circular Dichroism technique has been applied to investigate the conformational changes of the interactions of metal complexes with DNA. Also thermal behavior of DNA-complex interaction has been determined. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：1 / 8

页数：8

共 66 条

[1]

Abedi A., 2016, J IRAN CHEM SOC, P1

[2] Cytotoxicity and DNA/BSA binding ability of copper(II) complexes with dimethylbithiazole [J].

Abedi, Anita ;

Lighvan, Zohreh Mehri ;

Ostad, S. Nasser .

MONATSHEFTE FUR CHEMIE, 2016, 147 (09) :1651-1658

[3] High nuclearity nickel compounds with three, four or five metal atoms showing antibacterial activity [J].

Alexiou, M ;

Tsivikas, I ;

Dendrinou-Samara, C ;

Pantazaki, AA ;

Trikalitis, P ;

Lalioti, N ;

Kyriakidis, DA ;

Kessissoglou, DP .

JOURNAL OF INORGANIC BIOCHEMISTRY, 2003, 93 (3-4) :256-264

[4]

[Anonymous], 2005, SAINT VERS 7 06A

[5]

[Anonymous], SADABS VERSION 2 10

[6]

[Anonymous], 2005, COSMO VERS 1 60

[7] Synthesis, spectral, thermal and electrochemical studies of nickel (II) complexes with N2O2 donor ligands [J].

Anthonysamy, A ;

Balasubramanian, S .

INORGANIC CHEMISTRY COMMUNICATIONS, 2005, 8 (10) :908-911

[8] Synthesis and characterization of new chiral Schiff base complexes with diiminobinaphthyl or diiminocyclohexyl moieties as potential enantioselective epoxidation catalysts [J].

Bernardo, K ;

Leppard, S ;

Robert, A ;

Commenges, G ;

Dahan, F ;

Meunier, B .

INORGANIC CHEMISTRY, 1996, 35 (02) :387-396

[9] Synthesis, Electronic Structure, DNA and Protein Binding, DNA Cleavage, and Anticancer Activity of Fluorophore-Labeled Copper(II) Complexes [J].

Bhat, Satish S. ;

Kumbhar, Anupa A. ;

Heptullah, Hussain ;

Khan, Ayesha A. ;

Gobre, Vivekanand V. ;

Gejji, Shridhar P. ;

Puranik, Vedavati G. .

INORGANIC CHEMISTRY, 2011, 50 (02) :545-558

[10]

Bordbar M., 2015, MET ORG NANO MET CHE, V45, P1882

← 1 2 3 4 5 6 7 →