A new rearranged abietane diterpene from Clerodendrum inerme with antioxidant and cytotoxic activities

被引：22

作者：

Le Ba Vinh ^{[1
,2
]}

Nguyen Thi Minh Nguyet ^{[1
]}

Yang, Seo Young ^{[1
]}

Kim, Jang Hoon ^{[3
]}

Le Thi Vien ^{[2
]}

Phan Thi Thanh Huong ^{[2
]}

Nguyen Van Thanh ^{[2
]}

Nguyen Xuan Cuong ^{[2
]}

Nguyen Hoai Nam ^{[2
]}

Chau Van Minh ^{[2
]}

Inkyu Hwang ^{[1
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Daejeon, South Korea

[2] VAST, Inst Marine Biochem IMBC, Hanoi, Vietnam

[3] Korea Atom Energy Res Inst, Jeongeup, South Korea

来源：

NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 17期

基金：

新加坡国家研究基金会;

关键词：

Clerodendrum inerme; Verbenaceae; abietane diterpene; crolerodendrum B; antioxidant; cytotoxic; CONSTITUENTS; FLAVONOIDS; GLUCOSIDE; LEAVES; FUNGUS;

D O I：

10.1080/14786419.2017.1360885

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Eight compounds were isolated from the leaves of Clerodendrum inerme, including one new rearranged abietane diterpene, crolerodendrum B (1). Their structures were determined by means of spectroscopic methods including one-dimensional and two-dimensional nuclear magnetic resonance (1-D and 2-DNMR), high-resolution electrospray ionisation mass spectrometry (HR-ESI-MS) and circular dichroism (CD). The DPPH radical scavenging and cytotoxic activities of isolated compounds against MCF7 (breast), HCT116 (colon) and B16F10 (melanoma) cancer cell lines were evaluated. Compounds 1, 3 and 4 exhibited strong DPPH radical-scavenging effects (ED50 values of 17.6 +/- 2.1, 10.1 +/- 0.8 and 11.3 +/- 0.3M, respectively) and 4 showed strong cytotoxicity against the HCT116 cell line (IC50=3.46 +/- 0.01 mu M). [GRAPHICS] .

引用

页码：2001 / 2007

页数：7

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