Recent advancement of imidazolate framework (ZIF-8) based nanoformulations for synergistic tumor therapy

被引：130

作者：

Gao, Lihua ^{[1
]}

Chen, Qing ^{[2
]}

Gong, Tingting ^{[1
]}

Liu, Jianhua ^{[1
]}

Li, Chunxia ^{[2
]}

机构：

[1] Second Hosp Jilin Univ, Dept Radiol, Changchun 130041, Jilin, Peoples R China

[2] Zhejiang Normal Univ, Dept Chem, Jinhua 321004, Zhejiang, Peoples R China

来源：

NANOSCALE | 2019年 / 11卷 / 44期

基金：

中国国家自然科学基金;

关键词：

METAL-ORGANIC-FRAMEWORK; MESOPOROUS SILICA NANOPARTICLES; UP-CONVERSION NANOPARTICLES; CORE-SHELL NANOPARTICLES; RESPONSIVE DRUG-RELEASE; ONE-POT SYNTHESIS; IN-VIVO; PHOTODYNAMIC THERAPY; JANUS NANOPARTICLES; INDOCYANINE GREEN;

D O I：

10.1039/c9nr06558j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

As a new kind of porous material, zeolitic imidazolate frameworks (ZIF-8) are built from zinc ions and 2-methylimidazolate and possess unique merits including high porosity, good structural regularity and tunability, adjustable surface functionality and intrinsic pH induced biodegradability. These advantages endow ZIF-8 with multiple functionalities and stimuli-responsive controlled release of loaded payloads by endogenous or exogenous means. In this review, we will summarize the recent advancement of ZIF-8 as nanocarriers for the loading of various molecules including chemotherapeutic drugs, photosensitizers, photothermal agents, and proteins to fabricate multifunctional nanocomposites for synergistic cancer therapy. In addition, the challenges and future developments in this area will be highlighted.

引用

页码：21030 / 21045

页数：16

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