Serum free fatty acid elevation is related to acute kidney injury in primary nephrotic syndrome

被引：6
作者：
Zhang, Lili [1 ]
Cui, Li [2 ]
Li, Chunmei [2 ]
Zhao, Xiangzhong [3 ]
Lai, Xiaoying [2 ]
Li, Jing [1 ]
Lv, Teng [4 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Dept Nutr, Qingdao, Peoples R China
[2] Qingdao Univ, Affiliated Hosp, Dept Nephrol, Qingdao, Peoples R China
[3] Qingdao Univ, Affiliated Hosp, Med Res Ctr, Qingdao, Peoples R China
[4] Qingdao Univ, Affiliated Hosp, Dept Gynecol, 1677,Wutaishan Rd, Qingdao 266000, Peoples R China
来源：
RENAL FAILURE | 2022年 / 44卷 / 01期
关键词：
Acute kidney injury; fatty acid; nephrotic syndrome; biomarker; acute tubular necrosis; MINIMAL-CHANGE DISEASE; LIPID-METABOLISM; RENAL-FAILURE; RISK; EPIDEMIOLOGY; CHILDHOOD; SECRETION; AKI;
D O I：
10.1080/0886022X.2022.2105232
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The aim of this research was to examine the clinical characteristics of acute kidney injury (AKI) in primary nephrotic syndrome (NS) and discuss the relationship between serum lipids and AKI. A total of 1028 patients diagnosed with primary NS with renal biopsy results were enrolled in this study. The patients were divided into AKI (n = 81) and non-AKI (n = 947) groups, and their characteristics were compared using a propensity score analysis for the best matching. Serum free fatty acid (FFA) was an independent predictor for AKI in the postmatch samples (p = 0.011). No significant difference in FFA levels was observed among AKI stages or different pathological types in the AKI and non-AKI groups. The AUC (area under the ROC curve) was 0.63 for FFA levels to distinguish AKI. In primary NS, elevated FFA levels tend to be related to a high risk of AKI. FFAs have diagnostic value and may serve as biomarkers for AKI in NS.
引用
收藏
页码：1236 / 1242
页数：7
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