Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sjogren's syndrome

被引：15

作者：

Klussmann, JP ^{[1
]}

Wagner, M

Guntinas-Lichius, O

Müller, A

机构：

[1] Univ Cologne, HNO Klin, Dept Otorhinolaryngol, D-50924 Cologne, Germany

[2] Univ Cologne, Dept Pathol, D-50924 Cologne, Germany

[3] Univ Cologne, Dept Internal Med 1, D-50924 Cologne, Germany

来源：

JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2003年 / 32卷 / 04期

关键词：

human herpes virus 8; MALT lymphoma; Sjogren's syndrome; salivary gland tumor;

D O I：

10.1034/j.1600-0714.2003.00092.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

We describe the case of a bilateral parotid mucosa-associated lymphoid tissue (MALT) lymphoma associated with 2 years history of Sjogren's syndrome (SS), which was linked to human herpes virus 8 (HHV-8) infection. Using polymerase chain reaction (PCR) assay HHV-8 sequences were detectable in the lymphoma tissue of both sides. Serologic testing of the patient revealed HHV-8 antibodies in enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA). Immunohistologic staining with two antibodies against open reading frame (ORF) 26 and v-cyclin homologues of HHV-8 revealed positive staining of the salivary acinic cells whereas the lymphoma cells were negative. The potential influence of HHV-8 infection for MALT lymphoma development in this case and possible parallels to gastric MALT lymphoma are discussed.

引用

页码：243 / 245

页数：3

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