Detection of HHV-8 sequences and antigens in a MALT lymphoma associated with Sjogren's syndrome

被引：15
|
作者：
Klussmann, JP [1 ]
Wagner, M
Guntinas-Lichius, O
Müller, A
机构：
[1] Univ Cologne, HNO Klin, Dept Otorhinolaryngol, D-50924 Cologne, Germany
[2] Univ Cologne, Dept Pathol, D-50924 Cologne, Germany
[3] Univ Cologne, Dept Internal Med 1, D-50924 Cologne, Germany
来源：
JOURNAL OF ORAL PATHOLOGY & MEDICINE | 2003年 / 32卷 / 04期
关键词：
human herpes virus 8; MALT lymphoma; Sjogren's syndrome; salivary gland tumor;
D O I：
10.1034/j.1600-0714.2003.00092.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
We describe the case of a bilateral parotid mucosa-associated lymphoid tissue (MALT) lymphoma associated with 2 years history of Sjogren's syndrome (SS), which was linked to human herpes virus 8 (HHV-8) infection. Using polymerase chain reaction (PCR) assay HHV-8 sequences were detectable in the lymphoma tissue of both sides. Serologic testing of the patient revealed HHV-8 antibodies in enzyme-linked immunosorbent assay (ELISA) and immunofluorescence assay (IFA). Immunohistologic staining with two antibodies against open reading frame (ORF) 26 and v-cyclin homologues of HHV-8 revealed positive staining of the salivary acinic cells whereas the lymphoma cells were negative. The potential influence of HHV-8 infection for MALT lymphoma development in this case and possible parallels to gastric MALT lymphoma are discussed.
引用
收藏
页码：243 / 245
页数：3
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