Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats

被引：17
作者：
Bazinet, RP [1 ]
Douglas, H [1 ]
Cunnane, SC [1 ]
机构：
[1] Univ Toronto, Fac Med, Dept Nutr Sci, Toronto, ON, Canada
来源：
LIPIDS | 2003年 / 38卷 / 02期
关键词：
D O I：
10.1007/s11745-003-1050-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We evaluated the utilization of alpha-linolenic acid (18:3n-3) in growing rats consuming a diet deficient in n-6 PUFA. After 90 d, whole-body 18:3n-3 accumulation was 55% lower, total n-3 PUFA accumulation was 21% lower, and 18:3n-3 disappearance was 14% higher in n-6 PUFA-deficient rats. Part of the reduction of whole-body 18:3n-3 in n-6 PUFA-deficient rats was due to the 25% increase in net conversion of 18:3n-3 to long-chain n-3 PUFA. Despite adequate 18:3n-3 intake, n-6 PUFA deficiency decreased the accumulation of 18:3n-3 and total n-3 PUFA.
引用
收藏
页码：187 / 189
页数：3
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