Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis

被引：14

作者：

Broadley, James ^{[1
,2
]}

Wesselingh, Robb ^{[1
,2
]}

Seneviratne, Udaya ^{[1
,3
,4
]}

Kyndt, Chris ^{[5
]}

Beech, Paul ^{[7
,8
]}

Buzzard, Katherine ^{[5
,9
]}

Nesbitt, Cassie ^{[2
,10
]}

D'Souza, Wendyl ^{[4
]}

Brodtmann, Amy ^{[5
,11
]}

Macdonell, Richard ^{[11
]}

Kalincik, Tomas ^{[6
,13
]}

Butzkueven, Helmut ^{[1
,2
]}

O'Brien, Terence J. ^{[1
,2
]}

Monif, Mastura ^{[1
,2
,9
,12
]}

机构：

[1] Monash Univ, Dept Neurosci, Melbourne, Vic, Australia

[2] Alfred Hlth, Dept Neurol, Melbourne, Vic, Australia

[3] Monash Hlth, Dept Neurosci, Melbourne, Vic, Australia

[4] Univ Melbourne, St Vincents Hosp, Dept Med, Melbourne, Vic, Australia

[5] Eastern Hlth, Dept Neurosci, Melbourne, Vic, Australia

[6] Univ Melbourne, Dept Med, Melbourne, Vic, Australia

[7] Alfred Hlth, Dept Radiol, Melbourne, Vic, Australia

[8] Monash Hlth, Dept Radiol, Melbourne, Vic, Australia

[9] Melbourne Hlth, Dept Neurol, Melbourne, Vic, Australia

[10] Barwon Hlth, Dept Neurosci, Geelong, Vic, Australia

[11] Austin Hlth, Dept Neurol, Geelong, Vic, Australia

[12] Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia

[13] Univ Melbourne, CORe, Melbourne, Vic, Australia

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 353卷

关键词：

Autoimmune encephalitis; CSF; Lymphocytosis; Prognosis; Biomarker; RECEPTOR ENCEPHALITIS; LIMBIC ENCEPHALITIS; PREDICTIVE-VALUE; CASE SERIES; DIAGNOSIS; IMMUNOTHERAPY; RITUXIMAB;

D O I：

10.1016/j.jneuroim.2021.577508

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Objective: To examine the prognostic value of CSF abnormalities in seropositive autoimmune encephalitis (AE). Methods: We retrospectively studied 57 cases of seropositive AE. Primary outcomes were mortality and modified Rankin Scale, while secondary outcomes were first line treatment failure, ICU admission and relapse. Regression analysis was performed. Results: CSF white cell count (WCC) was higher in the NMDAR group, while elevated protein was more common amongst other subtypes. We found an association between WCC >5 cells/mm(3) and treatment failure (OR 16.0, p = 0.006)), and between WCC >20 cells/mm(3) and ICU admission (OR 19.3, p = 0.026). Conclusions: Different subsets of AE have characteristic CSF abnormalities, which may aid recognition during early evaluation. CSF WCC had prognostic significance in our study.

引用

页数：8

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