Prognostic value of acute cerebrospinal fluid abnormalities in antibody-positive autoimmune encephalitis

被引：14
|
作者：
Broadley, James [1 ,2 ]
Wesselingh, Robb [1 ,2 ]
Seneviratne, Udaya [1 ,3 ,4 ]
Kyndt, Chris [5 ]
Beech, Paul [7 ,8 ]
Buzzard, Katherine [5 ,9 ]
Nesbitt, Cassie [2 ,10 ]
D'Souza, Wendyl [4 ]
Brodtmann, Amy [5 ,11 ]
Macdonell, Richard [11 ]
Kalincik, Tomas [6 ,13 ]
Butzkueven, Helmut [1 ,2 ]
O'Brien, Terence J. [1 ,2 ]
Monif, Mastura [1 ,2 ,9 ,12 ]
机构：
[1] Monash Univ, Dept Neurosci, Melbourne, Vic, Australia
[2] Alfred Hlth, Dept Neurol, Melbourne, Vic, Australia
[3] Monash Hlth, Dept Neurosci, Melbourne, Vic, Australia
[4] Univ Melbourne, St Vincents Hosp, Dept Med, Melbourne, Vic, Australia
[5] Eastern Hlth, Dept Neurosci, Melbourne, Vic, Australia
[6] Univ Melbourne, Dept Med, Melbourne, Vic, Australia
[7] Alfred Hlth, Dept Radiol, Melbourne, Vic, Australia
[8] Monash Hlth, Dept Radiol, Melbourne, Vic, Australia
[9] Melbourne Hlth, Dept Neurol, Melbourne, Vic, Australia
[10] Barwon Hlth, Dept Neurosci, Geelong, Vic, Australia
[11] Austin Hlth, Dept Neurol, Geelong, Vic, Australia
[12] Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia
[13] Univ Melbourne, CORe, Melbourne, Vic, Australia
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2021年 / 353卷
关键词：
Autoimmune encephalitis; CSF; Lymphocytosis; Prognosis; Biomarker; RECEPTOR ENCEPHALITIS; LIMBIC ENCEPHALITIS; PREDICTIVE-VALUE; CASE SERIES; DIAGNOSIS; IMMUNOTHERAPY; RITUXIMAB;
D O I：
10.1016/j.jneuroim.2021.577508
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Objective: To examine the prognostic value of CSF abnormalities in seropositive autoimmune encephalitis (AE). Methods: We retrospectively studied 57 cases of seropositive AE. Primary outcomes were mortality and modified Rankin Scale, while secondary outcomes were first line treatment failure, ICU admission and relapse. Regression analysis was performed. Results: CSF white cell count (WCC) was higher in the NMDAR group, while elevated protein was more common amongst other subtypes. We found an association between WCC >5 cells/mm(3) and treatment failure (OR 16.0, p = 0.006)), and between WCC >20 cells/mm(3) and ICU admission (OR 19.3, p = 0.026). Conclusions: Different subsets of AE have characteristic CSF abnormalities, which may aid recognition during early evaluation. CSF WCC had prognostic significance in our study.
引用
收藏
页数：8
相关论文
共 50 条
  • [1] Epidemiology of Antibody-Positive Autoimmune Encephalitis in Southwest China: A Multicenter Study
    Gu, Yixue
    Zhong, Min
    He, Liang
    Li, Wei
    Huang, Yuanyuan
    Liu, Jing
    Chen, Yangmei
    Xiao, Zheng
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [2] Higher incidence of acute symptomatic seizures in probable antibody-negative pediatric autoimmune encephalitis than in major antibody-positive autoimmune encephalitis
    Yamada, Naoki
    Inoue, Takeshi
    Kuki, Ichiro
    Yamamoto, Naohiro
    Fukuoka, Masataka
    Nukui, Megumi
    Okuno, Hideo
    Ishikawa, Junichi
    Amo, Kiyoko
    Togawa, Masao
    Sakuma, Hiroshi
    Okazaki, Shin
    FRONTIERS IN NEUROLOGY, 2024, 15
  • [3] Commentary: Epidemiology of Antibody-Positive Autoimmune Encephalitis in Southwest China: A Multicenter Study
    Zhou, Yanbing
    Meng, Zirui
    Ying, Binwu
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [4] Cerebrospinal fluid YKL-40 level evolution is associated with autoimmune encephalitis remission
    Dorcet, Guillaume
    Benaiteau, Marie
    Pariente, Jeremie
    Ory-Magne, Fabienne
    Cheuret, Emmanuel
    Rafiq, Marie
    Brooks, Wesley
    Puissant-Lubrano, Benedicte
    Fortenfant, Francoise
    Renaudineau, Yves
    Bost, Chloe
    CLINICAL & TRANSLATIONAL IMMUNOLOGY, 2023, 12 (03)
  • [5] Predictors and prognoses of epilepsy after anti-neuronal antibody-positive autoimmune encephalitis
    Chen, Shan-Shan
    Zhang, Yan-Fang
    Di, Qing
    Shi, Jing-Ping
    Wang, Ling-Ling
    Lin, Xing-Jian
    Yu, Nian
    SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2021, 92 : 189 - 194
  • [6] Mind the Gap: Seronegative but Cerebrospinal Fluid Antibody-Positive Anti-N-Methyl-D-Aspartate Receptor Encephalitis
    Pandey, Sanjay
    Balint, Bettina
    MOVEMENT DISORDERS CLINICAL PRACTICE, 2020, 7 (05): : 500 - 501
  • [7] Cerebrospinal fluid biomarkers in psychiatric autoimmune encephalitis: a retrospective cohort study
    Hansen, Niels
    Juhl, Aaron Levin
    Grenzer, Insa Maria
    Teegen, Bianca
    Wiltfang, Jens
    Fitzner, Dirk
    FRONTIERS IN PSYCHIATRY, 2023, 14
  • [8] Cerebrospinal Fluid Findings in Patients With Autoimmune Encephalitis-A Systematic Analysis
    Blinder, Tetyana
    Lewerenz, Jan
    FRONTIERS IN NEUROLOGY, 2019, 10
  • [9] A case report of anti-GAD65 antibody-positive autoimmune encephalitis in children associated with autoimmune polyendocrine syndrome type-II and literature review
    Sapana, Tamang
    Li, Wei
    Tian, Fengyan
    Yan, Wenhao
    Dou, Binghua
    Hua, Shuang
    Zhuo, Zhihong
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [10] Prognostic value of intrathecal antibody production and DNA viral load in cerebrospinal fluid of patients with herpes simplex encephalitis
    Hjalmarsson, Anders
    Granath, Fredrik
    Forsgren, Marianne
    Brytting, Maria
    Blomqvist, Paul
    Skoldenberg, Birgit
    JOURNAL OF NEUROLOGY, 2009, 256 (08) : 1243 - 1251
12345