Mood effects of repetitive transcranial magnetic stimulation of left prefrontal cortex in healthy volunteers

被引：65

作者：

Mosimann, UP ^{[1
]}

Rihs, TA ^{[1
]}

Engeler, J ^{[1
]}

Fisch, HU ^{[1
]}

Schlaepfer, TE ^{[1
]}

机构：

[1] Univ Hosp Bern, Dept Psychiat, Psychiat Neuroimaging Grp, CH-3010 Bern, Switzerland

来源：

PSYCHIATRY RESEARCH | 2000年 / 94卷 / 03期

关键词：

visual analog scales; affect; transcranial magnetic stimulation; prefrontal cortex;

D O I：

10.1016/S0165-1781(00)00146-3

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

This study investigated the effect of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) of the left prefrontal cortex (LPFC) on mood in a sham-controlled crossover design. Twenty-five healthy male subjects received HF-rTMS of the LPFC in real and sham conditions. Forty trains (frequency 20 Hz, stimulation intensity 100% of individual motor threshold, train duration 2 s, intertrain interval 28 s) were applied in each session. Mood change from baseline was measured with five visual analog scales (VAS) for sadness, anxiety, happiness, tiredness and pain/discomfort. We were unable to demonstrate significant mood changes from baseline on visual analog scales after either sham or real stimulation of LPFC. There is insufficient evidence to support the general conclusion that HF-rTMS of LPFC has mood effects in healthy volunteers. Future studies should be sham-controlled, have larger sample sizes, and strictly stimulate one single region per session in order to exclude interaction effects with the previous stimulation. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：251 / 256

页数：6

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