The Androgen Receptor Gene Mutations Database

被引：133

作者：

Gottlieb, B

Lehvaslaiho, H

Beitel, LK

Lumbroso, R

Pinsky, L

Trifiro, M

机构：

[1] Sir Mortimer B Davis Jewish Hosp, Lady Davis Inst Med Res, Quebec City, PQ H3T 1E2, Canada

[2] McGill Univ, Dept Med, Quebec City, PQ H3T 1E2, Canada

[3] McGill Univ, Dept Biol, Quebec City, PQ H3T 1E2, Canada

[4] McGill Univ, Dept Human Genet, Quebec City, PQ H3T 1E2, Canada

[5] John Abbott Coll, Dept Biol, Quebec City, PQ H9X 3L9, Canada

[6] European Bioinformat Inst, EMBL Outstn, Cambridge CB10 1SD, England

来源：

NUCLEIC ACIDS RESEARCH | 1998年 / 26卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1093/nar/26.1.234

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current version of the androgen receptor (AR) gene mutations database is described, The total number of reported mutations has risen from 272 to 309 in the past year, We have expanded the database: (i) by giving each entry an accession number; (ii) by adding information on the length of polymorphic polyglutamine (polyGln) and polyglycine (polyGly) tracts in exon 1; (iii) by adding information on large gene deletions; (iv) by providing a direct link with a completely searchable database (courtesy EMBL-European Bioinformatics Institute), The addition of the exon 1 polymorphisms is discussed in light of their possible relevance as markers for predisposition to prostate or brest cancer. The database is also available on the internet (http://www.mcgill.ca/androgendb/), from EMBL-European Bioinformatics Institute (ftp.ebi.ac.uk/pub/databases/androgen), or as a Macintosh FilemakerPro or Word file (MC33@musica.mcgill.ca).

引用

页码：234 / 238

页数：5

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