Changes in NADPH diaphorase reactivity and neuronal nitric oxide synthase in the rat retina following constant illumination

被引：8

作者：

Goldstein, J ^{[1
]}

LopezCosta, JJ ^{[1
]}

Saavedra, JP ^{[1
]}

机构：

[1] UNIV BUENOS AIRES,FAC MED,INST BIOL CELULAR & NEUROCIENCIA DR EDUARDO DE RO,RA-1121 BUENOS AIRES,DF,ARGENTINA

来源：

NEUROSCIENCE LETTERS | 1997年 / 231卷 / 01期

关键词：

nitric oxide; nicotinamide adenine dinucleotide phosphate diaphorase; illumination; rat; retina; photoreceptor; immunocytochemistry;

D O I：

10.1016/S0304-3940(97)00532-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The distribution of nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) reactivity and neuronal nitric oxide synthase immunoreactivity (nNOS-IR) was investigated in the rat retina during photoreceptor regeneration. Photoreceptor damage and the disappearance of a NADPHd reactive/nNOS-IR band corresponding to inner photoreceptor segments were observed after continuous exposure to light irradiation. Both events were reversible after 20 days of total darkness. Also a progressive decrease in the number and in the staining intensity of NADPHd reactivity in amacrine cells were found along the first 3-6 days of darkness stabilizing thereafter in both illuminated and control groups. However, staining intensity in the former group remained more elevated than in the latter one. NOS activity in the retina varies depending on functional and pathological states. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：45 / 48

页数：4

共 16 条

[11]

SAAVEDRA JP, 1976, CELL TISSUE RES, V166, P201

[12] A COMPARATIVE-STUDY OF NADPH-DIAPHORASE IN THE SYMPATHETIC PREGANGLIONIC NEURONS OF THE UPPER THORACIC CORD BETWEEN SPONTANEOUSLY HYPERTENSIVE RATS AND WISTAR-KYOTO RATS [J].