Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones

被引：53

作者：

Zhou, Yu ^{[1
]}

Zhai, Yun ^{[1
]}

Ji, Xun ^{[1
,2
]}

Liu, Guannan ^{[1
]}

Feng, Enguang ^{[1
]}

Ye, Deju ^{[1
]}

Zhao, Linxiang ^{[2
]}

Jiang, Hualiang ^{[1
]}

Liu, Hong ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, State Key Lab Drug Res, Shanghai 201203, Peoples R China

[2] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 2-3期

基金：

中国国家自然科学基金;

关键词：

alkynes; gold; pyrrolo-/pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones; tandem reactions; GOLD-CATALYZED CYCLOISOMERIZATIONS; CYCLIZATION; STEREOCENTERS; ALKYNES;

D O I：

10.1002/adsc.200900724

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A highly efficient method has been developed for the one-pot synthesis of multi-ring heterocyclic compounds Such as pyrrolo-/pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones from o-aminobenzyl alcohols via a gold(I)-catalyzed tandem coupling/cyclization reaction. Significantly, the strategy presents a straightforward and efficient approach to construct novel tricyclic or polycyclic molecular architectures in which two new C-N bonds and one C-O bond are formed in a one-pot reaction operation from two simple starting materials. Moreover, a broad spectrum Of Substrates can participate in the process effectively to produce the desired products in good yields.

引用

页码：373 / 378

页数：6

共 48 条

[1] New C2-symmetric diphosphite ligands derived from carbohydrates:: Effect of the remote stereocenters on asymmetric catalysis [J].