Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease

被引：68

作者：

Shao, D ^{[1
]}

Zou, CY ^{[1
]}

Luo, C ^{[1
]}

Tang, XC ^{[1
]}

Li, YC ^{[1
]}

机构：

[1] Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 18期

关键词：

tacrine-E2020; hybrids; acetylcholinesterase inhibitor; Alzheimer's disease;

D O I：

10.1016/j.bmcl.2004.07.005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tacrine-E2020 hybrids and some related compounds were prepared and their bioactivities on the Alzheimer's disease were assayed. The optimum hybrid inhibitor 3 is 37-fold more potent and 31-fold more selective than tacrine in vitro. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：4639 / 4642

页数：4

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