Clozapine, atypical antipsychotic drug, is widely used in patients with schizophrenia, for whom previous therapy was inadequate or not tolerated. Clozapine-induced myocarditis (CIM) is a relatively rare but potentially life-threatening complication of clozapine therapy; however, the underlying mechanism has not been so far well elucidated. Factors predisposing to CIM include a rapid dose titration, advanced age and co-administration of sodium valproate. In this paper, we present a case of a 22-year-old male patient with refractory schizophrenia who developed CIM during low-dose clozapine treatment with co-administration of valproate and risperidone. On the basis of our case and literature review, we point out that during the first weeks of clozapine treatment patients should be actively, daily monitored for the presence of symptoms suggesting CIM. The low dose of clozapine and concurrent use of valproate are unique aspects of the report, adding new information to the discussion on safety of concomitant use of clozapine and valproate. Further investigation is required to better understand the role of co-administration of valproate and risperidone in the pathogenesis of CIM.
机构:Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
Coulter, DM
Bate, A
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机构:Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
Bate, A
Meyboom, RHB
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机构:Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
Meyboom, RHB
Lindquist, M
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机构:Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
Lindquist, M
Edwards, IR
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Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, SwedenUppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
机构:
McLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Harvard Med Sch, Dept Psychiat, Boston, MA USA
Univ Roma La Sapienza, Dept Neurol & Psychiat, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Curto, Martina
Girardi, Nicoletta
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Univ Roma La Sapienza, Dept Neurol & Psychiat, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Girardi, Nicoletta
Lionetto, Luana
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IDI IRCCS, Adv Mol Diagnost Unit, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Lionetto, Luana
Ciavarella, Giuseppino M.
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Univ Roma La Sapienza, Dept Cardiol, St Andrea Med Ctr, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Ciavarella, Giuseppino M.
Ferracuti, Stefano
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Univ Roma La Sapienza, NESMOS Dept, St Andrea Med Ctr, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Ferracuti, Stefano
Baldessarini, Ross J.
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McLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Harvard Med Sch, Dept Psychiat, Boston, MA USAMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
机构:
N Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Glen Oaks, NY USA
Albert Einstein Coll Med, Bronx, NY 10467 USAAarhus Univ Hosp, Unit Psychiat Res, Aalborg Psychiat Hosp, DK-9100 Aalborg, Denmark
机构:Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
Coulter, DM
Bate, A
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机构:Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
Bate, A
Meyboom, RHB
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h-index: 0
机构:Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
Meyboom, RHB
Lindquist, M
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机构:Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
Lindquist, M
Edwards, IR
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h-index: 0
机构:
Uppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, SwedenUppsala Monitoring Ctr, WHO, Collaborating Ctr Int Drug Monitoring, S-75320 Uppsala, Sweden
机构:
McLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Harvard Med Sch, Dept Psychiat, Boston, MA USA
Univ Roma La Sapienza, Dept Neurol & Psychiat, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Curto, Martina
Girardi, Nicoletta
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Neurol & Psychiat, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Girardi, Nicoletta
Lionetto, Luana
论文数: 0引用数: 0
h-index: 0
机构:
IDI IRCCS, Adv Mol Diagnost Unit, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Lionetto, Luana
Ciavarella, Giuseppino M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, Dept Cardiol, St Andrea Med Ctr, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Ciavarella, Giuseppino M.
Ferracuti, Stefano
论文数: 0引用数: 0
h-index: 0
机构:
Univ Roma La Sapienza, NESMOS Dept, St Andrea Med Ctr, Rome, ItalyMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Ferracuti, Stefano
Baldessarini, Ross J.
论文数: 0引用数: 0
h-index: 0
机构:
McLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
Harvard Med Sch, Dept Psychiat, Boston, MA USAMcLean Hosp, Int Consortium Psychot & Mood Disorders, 115 Mill St, Belmont, MA 02178 USA
机构:
N Shore Long Isl Jewish Hlth Syst, Zucker Hillside Hosp, Glen Oaks, NY USA
Albert Einstein Coll Med, Bronx, NY 10467 USAAarhus Univ Hosp, Unit Psychiat Res, Aalborg Psychiat Hosp, DK-9100 Aalborg, Denmark