Clozapine-induced myocarditis during co-administration of valproate: A case report

被引:7
作者
Jaholkowski, Piotr [1 ,3 ]
Niewiadomska, Julita [2 ]
Wciorka, Jacek [1 ]
Kowalski, Miroslaw [2 ]
Switaj, Piotr [1 ]
机构
[1] Inst Psychiat & Neurol Warszawie, Klin Psychiat 1, Ul Sobieskiego 9, PL-02957 Warsaw, Poland
[2] Inst Kardiol Warszawie, Klin Wad Wrodzonych Serca, Warsaw, Poland
[3] Inst Psychiat & Neurol Warszawie, Zaklad Farmakol & Fizjol Osrodkowego Ukladu Nerwo, Warsaw, Poland
关键词
clozapine; myocarditis; C-reactive protein; troponin; valproate; SCHIZOPHRENIA; TITRATION; DRUGS;
D O I
10.12740/PP/105121
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Clozapine, atypical antipsychotic drug, is widely used in patients with schizophrenia, for whom previous therapy was inadequate or not tolerated. Clozapine-induced myocarditis (CIM) is a relatively rare but potentially life-threatening complication of clozapine therapy; however, the underlying mechanism has not been so far well elucidated. Factors predisposing to CIM include a rapid dose titration, advanced age and co-administration of sodium valproate. In this paper, we present a case of a 22-year-old male patient with refractory schizophrenia who developed CIM during low-dose clozapine treatment with co-administration of valproate and risperidone. On the basis of our case and literature review, we point out that during the first weeks of clozapine treatment patients should be actively, daily monitored for the presence of symptoms suggesting CIM. The low dose of clozapine and concurrent use of valproate are unique aspects of the report, adding new information to the discussion on safety of concomitant use of clozapine and valproate. Further investigation is required to better understand the role of co-administration of valproate and risperidone in the pathogenesis of CIM.
引用
收藏
页码:997 / 1002
页数:6
相关论文
共 13 条
  • [1] A double-blind comparative study of clozapine and risperidone in the management of severe chronic schizophrenia
    Azorin, JM
    Spiegel, R
    Remington, G
    Vanelle, JM
    Péré, JJ
    Giguere, M
    Bourdeix, I
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2001, 158 (08) : 1305 - 1313
  • [2] Cardiac lesions induced by neuroleptic drugs in the rabbit
    Belhani, D
    Frassati, D
    Mégard, R
    Tsibiribi, P
    Bui-Xuan, B
    Tabib, A
    Fanton, L
    Malicier, D
    Descotes, J
    Timour, Q
    [J]. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2006, 57 (03) : 207 - 212
  • [3] Clozapine: its impact on aggressive behavior among patients in a state psychiatric hospital
    Chengappa, KNR
    Vasile, J
    Levine, J
    Ulrich, R
    Baker, R
    Gopalani, A
    Schooler, N
    [J]. SCHIZOPHRENIA RESEARCH, 2002, 53 (1-2) : 1 - 6
  • [4] Clozapine-induced myocarditis may be associated with rapid titration: A case report verified with autopsy
    Chopra, Nitin
    de Leon, Jose
    [J]. INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE, 2016, 51 (01) : 104 - 115
  • [5] Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study
    Coulter, DM
    Bate, A
    Meyboom, RHB
    Lindquist, M
    Edwards, IR
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2001, 322 (7296): : 1207 - 1209
  • [6] Systematic Review of Clozapine Cardiotoxicity
    Curto, Martina
    Girardi, Nicoletta
    Lionetto, Luana
    Ciavarella, Giuseppino M.
    Ferracuti, Stefano
    Baldessarini, Ross J.
    [J]. CURRENT PSYCHIATRY REPORTS, 2016, 18 (07)
  • [7] How effective are second-generation antipsychotic drugs? A meta-analysis of placebo-controlled trials
    Leucht, S.
    Arbter, D.
    Engel, R. R.
    Kissling, W.
    Davis, J. M.
    [J]. MOLECULAR PSYCHIATRY, 2009, 14 (04) : 429 - 447
  • [8] Clozapine treatment for suicidality in schizophrenia - International Suicide Prevention Trial (InterSePT)
    Meltzer, HY
    Alphs, L
    Green, AI
    Altamura, AC
    Anand, R
    Bertoldi, A
    Bourgeois, M
    Chouinard, G
    Islam, Z
    Kane, J
    Krishnan, R
    Lindenmayer, JP
    Potkin, S
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2003, 60 (01) : 82 - 91
  • [9] A METHOD FOR ESTIMATING THE PROBABILITY OF ADVERSE DRUG-REACTIONS
    NARANJO, CA
    BUSTO, U
    SELLERS, EM
    SANDOR, P
    RUIZ, I
    ROBERTS, EA
    JANECEK, E
    DOMECQ, C
    GREENBLATT, DJ
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1981, 30 (02) : 239 - 245
  • [10] Predictors of Clozapine Response in Patients With Treatment-Refractory Schizophrenia Results From a Danish Register Study
    Nielsen, Jimmi
    Nielsen, Rene Ernst
    Correll, Christoph U.
    [J]. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 2012, 32 (05) : 678 - 683