Guide to Selecting a Biorecognition Element for Biosensors

被引：308

作者：

Morales, Marissa A. ^{[1
]}

Halpern, Jeffrey Mark ^{[1
]}

机构：

[1] Univ New Hampshire, Dept Chem Engn, Durham, NH 03824 USA

来源：

BIOCONJUGATE CHEMISTRY | 2018年 / 29卷 / 10期

关键词：

MOLECULARLY IMPRINTED POLYMERS; NUCLEIC-ACID BIOSENSORS; LABEL-FREE DETECTION; CHEMICAL SENSORS; BREAST-CANCER; ELECTROCHEMICAL SENSORS; TRANSPORT-PROPERTIES; DNA HYBRIDIZATION; PHAGE DISPLAY; APTAMER;

D O I：

10.1021/acs.bioconjchem.8b00592

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Biosensors are powerful diagnostic tools defined as having a biorecognition element for analyte specificity and a transducer for a quantifiable signal. There are a variety of different biorecognition elements, each with unique characteristics. Understanding the advantages and disadvantages of each biorecognition element and their influence on overall biosensor performance is crucial in the planning stages to promote the success of novel biosensor development. Therefore, this review will focus on selecting the optimal biorecognition element in the preliminary design phase for novel biosensors. Included is a review of the typical characteristics and binding mechanisms of various biorecognition elements, and how they relate to biosensor performance characteristics, specifically sensitivity, selectivity, reproducibility, and reusability. The goal is to point toward language needed to improve the design and development of biosensors toward clinical success.

引用

页码：3231 / 3239

页数：9

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