Role of Dendritic Cells in inflammation and Loss of Tolerance in the elderly

被引:101
作者
Agrawal, Anshu [1 ]
Agrawal, Sudhanshu [1 ]
Gupta, Sudhir [1 ]
机构
[1] Univ Calif Irvine, Dept Med, Div Basic & Clin Immunol, Irvine, CA 92717 USA
来源
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
基金
美国国家卫生研究院;
关键词
dendritic cells; inflammation; tolerance; aging; mucosa; REGULATORY T-CELLS; AGED SUBJECTS; PERIPHERAL-BLOOD; RESPONSES; EXPRESSION; IMMUNITY; ANTIGEN; TISSUE; DIFFERENTIATION; SPECIALIZATION;
D O I
10.3389/fimmu.2017.00896
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Dendritic cells (DCs) play an important role in advancing age-associated progressive decline in adaptive immune responses, loss of tolerance, and development of chronic inflammation. In aged humans, DCs secrete increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory and immune-regulatory cytokines. This may contribute to both chronic inflammation and loss of tolerance in aging. Aged DCs also display increased immune response against self-antigens contributing further to both inflammation and loss of tolerance. The secretion of innate protective cytokines such as type I and III interferons is decreased, and the function of DCs in airway remodeling and inflammation in aged is also compromised. Furthermore, the capacity of DCs to prime T cell responses also seems to be affected. Collectively, these changes in DC functions contribute to the immune dysfunction and inflammation in the elderly. This review only focuses on age-associated changes in DC function in humans.
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页数:8
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