Design, synthesis, and application of chiral electron-poor guanidines as hydrogen-bonding catalysts for the Michael reaction

被引：11
|
作者：
Thai, Karen [1 ]
Gravel, Michel [1 ]
机构：
[1] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada
来源：
TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 06期
基金：
加拿大自然科学与工程研究理事会; 加拿大创新基金会;
关键词：
1,3-DICARBONYL COMPOUNDS; ASYMMETRIC CATALYSIS; ALPHA; BETA-UNSATURATED IMIDES; BIFUNCTIONAL ORGANOCATALYST; THIOUREA; RECOGNITION; NITROALKENES; RECEPTORS; DONORS; NITROOLEFINS;
D O I：
10.1016/j.tetasy.2010.04.033
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The first chiral electron-poor guanidine organocatalysts were synthesized. The presence of a tunable electron-withdrawing group on the guanidine moiety allows for the modulation of the catalysts' activity. The application of this new class of organocatalysts to the Michael reaction is demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：751 / 755
页数：5
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