Efficient solvent-free synthesis of thiazolidin-4-ones from phenylhydrazine and 2,4-dinitrophenylhydrazine

被引：37
作者：
Neuenfeldt, Patricia D. [1 ]
Drawanz, Bruna B. [1 ]
Siqueira, Geonir M. [1 ]
Gomes, Claudia R. B. [2 ]
Wardell, Solange M. S. V. [2 ,3 ]
Flores, Alex F. C. [4 ]
Cunico, Wilson [1 ,2 ]
机构：
[1] Univ Fed Pelotas, Dept Quim Organ, BR-96010900 Pelotas, RS, Brazil
[2] Fundacao Oswaldo Cruz, Inst Tecnol Farmacos Farmanguinhos, BR-21041250 Rio De Janeiro, Brazil
[3] CHEMSOL, Aberdeen AB155NY, Scotland
[4] Univ Fed Santa Maria, Dept Quim, BR-97105900 Santa Maria, RS, Brazil
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 23期
关键词：
Solvent free; Thiazolidinones; Heterocycles; Hydrazones; MERCAPTOACETIC ACID; 1,3-THIAZOLIDIN-4-ONES; 4-THIAZOLIDINONES; DERIVATIVES; INHIBITORS;
D O I：
10.1016/j.tetlet.2010.04.026
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient solvent-free synthesis of thiazolidinones from reaction of mercaptoacetic acid, aldehydes (benzaldehyde and valeraldehyde) or ketones (cyclopentanone and cyclohexanone), and hydrazines (phenylhydrazine and 2,4-dinitrophenylhydrazine) is reported. The compounds were generally characterized by spectroscopic techniques and specifically for 2-cyclohexanyl-3-(N-phenyl)-1,3-thiazolidin-4-one by X-ray crystallography. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3106 / 3108
页数：3
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