Differential Associations of Interleukin 6 and Intestinal Fatty Acid-Binding Protein With Progressive Untreated HIV-1 Infection in Rakai, Uganda

被引：11

作者：

Olwenyi, Omalla A. ^{[1
]}

Naluyima, Prossy ^{[1
,2
]}

Cham, Fatim ^{[1
,3
]}

Quinn, Thomas C. ^{[4
,5
]}

Serwadda, David ^{[6
,7
]}

Sewankambo, Nelson K. ^{[7
,8
]}

Gray, Ronald H. ^{[9
]}

Sandberg, Johan K. ^{[2
]}

Michael, Nelson L. ^{[10
]}

Wabwire-Mangen, Fred ^{[1
,6
]}

Robb, Merlin L.

Eller, Michael A.

机构：

[1] Makerere Univ Walter Reed Project, Kampala, Uganda

[2] Karolinska Univ, Huddinge Hosp, Karolinska Inst, Ctr Infect Med,Dept Med, Stockholm, Sweden

[3] Henry M Jackson Fdn Adv of Mil Med, Bethesda, MD USA

[4] NIAID, Immunoregulat Lab, Div Intramural Res, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[5] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[6] Makerere Univ, Coll Hlth Sci, Sch Publ Hlth, Kampala, Uganda

[7] Uganda Virus Res Inst, Rakai Hlth Sci Program, Entebbe, Uganda

[8] Makerere Univ, Coll Hlth Sci, Fac Med, Kampala, Uganda

[9] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Baltimore, MD USA

[10] Walter Reed Army Inst Res, US Mil HIV Res Program, Silver Spring, MD USA

来源：

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 01期

关键词：

HIV-1; AIDS; immune activation; inflammation; IL-6; IFABP; C-REACTIVE PROTEIN; T-CELL DEPLETION; SYSTEMIC IMMUNE ACTIVATION; DISEASE PROGRESSION; MICROBIAL TRANSLOCATION; PREDICT MORTALITY; VIRAL LOAD; SUBTYPE; MECHANISM; DECLINE;

D O I：

10.1097/QAI.0000000000000915

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The significance of HIV-associated immune activation and microbial translocation in Sub-Saharan African population remains poorly defined. We assessed biomarkers of inflammation, microbial translocation, and cellular activation and found most factors elevated in Ugandan HIV-1 seroconverters compared with community-matched controls. In contrast to previous findings in Western cohorts, C-reactive protein, neopterin, and intestinal fatty acid binding protein were not elevated. Higher T-cell activation and IL-6 were associated with faster disease progression. Surprisingly, intestinal fatty acid binding protein, indicative of enterocyte turnover, was higher in slow than in fast progressors. These data suggest differential relationships among biomarkers of intestinal barrier integrity and innate immune activation between developed countries and Sub-Saharan Africa.

引用

页码：15 / 20

页数：6

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